Beyond ICD codes: Unlocking rare disease insights with genomics and claims-based data

Description:

Rare disease research begins with understanding the underlying biology. GeneDx Infinity - the world's largest clinically interpreted rare disease database - combines clinically generated genomic data and expert interpretation to help biopharma identify the right patients and better understand disease biology. When linked with Komodo Health's longitudinal claims-based data, researchers gain a more complete view of the patient journey, connecting genetic insights to treatment patterns, healthcare utilization, and long-term outcomes.


Join experts from GeneDx and Komodo Health to explore how integrated genomic and claims-based data can improve patient finding, enable more precise rare disease cohorts, and generate higher-confidence real-world evidence across the drug development lifecycle. The session will also demonstrate how GeneDx Infinity and Komodo's AI-first capabilities, including Marmot, help transform complex datasets into actionable insights for discovery, clinical development, and post-launch evidence generation.

Speakers:
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Lisa Gurry

Chief Business Officer, GeneDx

Lisa Gurry is the Chief Business Officer at GeneDx, where she leads strategic growth across biopharma, health systems, and partners to advance precision medicine. She oversees strategic partnerships, biopharma partnerships, data product strategy, marketing and communications, helping unlock the full potential of GeneDx Infinity, the world’s largest clinically interpreted genomic dataset. Lisa brings deep expertise at the intersection of healthcare, technology, and data, with a strong track record of scaling innovative businesses. She co-founded Truveta, where she held roles including Chief Growth Officer, Chief Marketing Officer, and Chief Operating Officer. Earlier in her career, she spent more than 20 years at Microsoft.

Colleen Caleshu

Senior Director of Translational Research

Colleen Caleshu is a clinician-scientist leader and genetic counselor with more than 23 years of experience in genomic medicine and real-world data, including over a decade collaborating with rare disease biopharma organizations. As Senior Director of Translational Research at GeneDx, she leverages GeneDx Infinity, the world’s largest clinically interpreted genomic dataset, to lead research and real-world evidence strategies that support biopharma partners across evidence generation, study design, and clinical trial-enabling patient cohort development. She is currently completing a PhD in clinical trial methodology at Leiden University. Her research, along with 47 peer-reviewed publications and more than 60 conference presentations, spans clinical trials, natural history studies, variant interpretation, and LLM-based real-world data methodology. She is an internationally recognized expert in cardiovascular genetics, having established and led genetics programs embedded in cardiology at Stanford and UCSF.

Rathi Suresh

VP of Analytics, Komodo Health

Rathi Suresh is the Vice President of Analytics at Komodo Health, delivering analytical studies to help customers define scientific questions, set analytical strategy, and generate evidence that withstands regulatory and scientific scrutiny. Rathi brings more than 15 years of experience advising healthcare organizations across commercial strategy, analytics, and market research. She spent nearly a decade at Blueprint Research Group, where she became the company’s first non-founding partner, and later served as its West Coast lead following Blueprint’s acquisition by Trinity Life Sciences. She also serves as a Founding Limited Partner in Neythri Futures Fund, a VC fund founded by South Asian women investing in companies led by diverse teams. Rathi holds a PhD in Genetics from Columbia University, and she is passionate about democratizing access to real-world data and helping healthcare and life sciences organizations integrate AI into their analytics workflows.

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