Provider FAQs & Support

Given the large number of genes analyzed via exome or genome sequencing, variants may be detected in genes that may be medically significant, but not associated with the primary reason for testing in a given patient.

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In rare cases, GeneDx may report an additional reportable finding in a gene not associated with the patient’s reported phenotype and that is not one of the secondary findings genes recommended by the ACMG. These reported findings are expected to be medically relevant and will typically be pediatric-onset conditions. When these findings are identified, our clinical team is available to discuss the finding in detail with the ordering provider. Note that adult-onset, neurodegenerative disorders will not be reported in presymptomatic patients.

The diagnostic rate is highest when a trio is submitted and analyzed, as the inclusion of parental data improves the ability to classify variants. The absence of parental data may lead to higher rates of variants of unknown significance that could otherwise be dismissed based on inheritance patterns.

1. Clark MM, Stark Z, Farnaes L, et al. Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases. NPJ Genom Med. 2018 Jul 9;3:16. doi: 10.1038/s41525-018-0053-8. eCollection 2018.

By analyzing the entirety of an individual’s DNA, genome sequencing can enable the greatest chance of uncovering the underlying cause of a patient’s symptoms or condition.
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Please visit the genome homepage to learn about the benefits of genome sequencing and visit our test catalog to learn more about GeneDx’s test.

By analyzing the protein-coding regions of approximately 20,000 genes, exome sequencing can identify genetic changes that may be the underlying cause of a patient’s symptoms or condition.  

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Please visit the exome homepage to learn about the benefits of exome sequencing and visit our test catalog to learn more about GeneDx’s test.

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In addition to findings related to the patient’s symptoms, exome and genome sequencing sometimes identify genetic variants unrelated to the reason testing was ordered, called secondary findings.  

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The American College of Medical Genetics and Genomics (ACMG) has created a list of specific “secondary finding” genes known to be associated with health conditions for which medical screening and/or treatments are available. Most of these conditions can increase the chances of developing certain cancers or heart conditions, or change the way a person’s body breaks down, stores, and uses different substances (called metabolic conditions). Certain conditions, such as Alzheimer’s and Huntington’s disease, are not included.

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To help patients understand secondary findings, GeneDx has created this patient guide. It includes information on how to opt-in or opt-out of receiving secondary findings.

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Yes. Please call 888-729-1206 and ask to speak with a genetic counselor. You can also email Support@GeneDx.com to be put in touch with a GeneDx expert to address your questions.

We’ve partnered with Genome Medical, a medical practice specializing in telehealth genetic services. You can refer your patient by clicking on this link.

Specimen requirements and stability information varies based on the sample type. Please visit our Specimen requirements page to find details about the stability of a specific sample type.

The turnaround time will vary depending on the specific test ordered. Please see our test catalog for additional information on each test. Please note that turnaround times are estimates and begin after billing and clinical reviews are complete, when the sample(s) begin processing at the GeneDx lab. Turnaround times could be extended in situations outside GeneDx’s control.

To learn about our ordering process, including what’s required, how to order online, and alternative ordering methods, please visit our How to Order homepage.

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The most efficient way to place an order is via our online Provider Portal.

DNA samples can be collected in-office, or you can mail cheek swab (buccal) collection kits to the home of your patients and their family members.

To request that GeneDx send collection kits to your patients and their family members directly, simply include the request when placing an order via the GeneDx Provider Portal. You may also order kits on our supplies webpage or by emailing Support@GeneDx.com. Please note that kits cannot be sent to a P.O. box.

Yes! We’ve partnered with Genome Medical, a medical practice specializing in telehealth genetic services. You can refer your patient by clicking on this link.

GeneDx accepts specimens from certain countries outside of the United States. We are unable to accept orders or specimens from the United Kingdom (UK) or European Union (EU) countries at this time.

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If you have questions about placing an order or sending a specimen from another non-U.S. country, please email Support@GeneDx.com to discuss country-specific options and inquire about the preferred specimen type.

Biological parents typically provide the most informative specimens and are preferred whenever possible. If parents are unavailable, other relatives may be considered on a case-by-case basis. To review details of a specific case, please contact a GeneDx Genetic Counselor at Support@GeneDx.com or 888-729-1206.

Please visit our provider billing homepage to learn about our billing policies, what’s required for insurance billing, and our Patient Access Solutions, including our Financial Assistance Program.

If your patient has questions about their GeneDx bill, please have them contact our Billing team at Billing@GeneDx.com or 888‑729‑1206. If they have questions about their insurance coverage and benefits, please direct them to contact their insurance provider directly.

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GeneDx offers a patient-friendly billing postcard with information on what to expect from the GeneDx commercial billing process, how to learn more about our Financial Assistance Program, and how to get in contact with our Billing team.

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The final cost for any exome and genome sequencing will depend on the payment option selected. If your patient is using insurance benefits, they may have a final out-of-pocket expense depending on their plan terms, remaining deductible and co-insurance, if applicable. To learn more, please visit our provider billing homepage.

GeneDx LLC Tax Identification Number is 205446298.

GeneDx LLC National Provider Identifier (NPI) number is 1487632998.

Yes, our CAP ID number is 7205671. A copy of our licenses and certifications can be viewed here.

Yes, our CLIA ID number is 21D0969951. A copy of our licenses and certifications can be viewed here.

If you have an assigned Regional Account Executive or Client Success Manager, you can reach out to them directly.

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Otherwise, our Client Services team is happy to assist you. Find contact information here.

To learn what information is collected when using our website and online Provider Portal and interacting with our third-party partners, please see our privacy policy page. To view GeneDx’s HIPAA Notice of Privacy Practices, please see here.

Yes. We accept specimens from other laboratories and can also mail specimens to other laboratories.

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If you request that another lab send a specimen to GeneDx, please request tracking information from the sending laboratory. You’re welcome to check with GeneDx at any time to confirm if the sample has arrived.

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To request that GeneDx send a specimen to another laboratory, the ordering provider or a patient must complete a Specimen Send-Out Form, which can be obtained by emailing Support@GeneDx.com. Please be sure to supply a FedEx account number for payment. Please return the completed form by emailing it to Support@GeneDx.com or by faxing it to 201-421-2010. We will then send the specimen to the requested lab.

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