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Key takeaways
- Start with an exome-first approach that may better align with payer requirements and patient access while preserving a seamless path to genome analysis when needed.
- Avoid delays and administrative burden with one order and one sample, even when broader genomic analysis is clinically indicated.
- Receive clinically relevant exome results in as soon as two weeks to support time-sensitive prenatal decision-making.
A testing pathway designed for the way prenatal care happens
Prenatal genetic testing can provide valuable insights to help clinicians understand a fetal phenotype, guide pregnancy management, and prepare families for next steps.
However, the right testing strategy is not the same for every patient.
Insurance coverage considerations, institutional requirements, clinical presentation, and provider preferences can all influence whether a clinician begins with exome or genome sequencing. Prenatal Exome-to-Genome Reflex was designed with that reality in mind.
This testing pathway allows providers to start with prenatal exome sequencing while preserving a seamless path to genome analysis when additional information is needed. If the initial exome result does not fully explain the fetal phenotype, the case automatically reflexes to genome interpretation without requiring a new order, additional specimen collection, or a restart of the testing process.
The result is a more flexible approach to prenatal genomic testing that balances speed, access, and comprehensive analysis.
Start with exome with genome ready when needed
Exome sequencing is an established tool for evaluating suspected genetic conditions and may align more closely with payer requirements than genome sequencing in some clinical situations.
With Prenatal Exome-to-Genome Reflex, providers can begin with an exome-first strategy while maintaining access to broader genome analysis if the exome interpretation does not fully explain the fetal phenotype.
The same case automatically progresses to genome interpretation, allowing care teams to expand the scope of analysis without additional administrative steps or delays. For providers and patients, the experience remains simple:
One order. One sample. A seamless path from exome to genome.
Get clinically relevant information sooner
In prenatal care, timing matters.
Prenatal Exome-to-Genome Reflex delivers exome results in as soon as two weeks, enabling providers to begin incorporating genomic findings into clinical decision-making as quickly as possible.
When additional analysis is needed, genome interpretation can be initiated immediately using the same sequencing data and specimen. Reflex genome results are available within 1 to 2 days after the exome report, helping providers access broader genomic insights without restarting the testing process.
Learn more
Explore Prenatal Exome-to-Genome Reflex and discover how GeneDx is helping prenatal providers access flexible, genome-backed testing pathways designed for real-world clinical care.
Order Prenatal Exome-to-Genome Reflex in Your EHR
Prenatal Exome-to-Genome Reflex is designed to simplify the testing experience from the start. As part of GeneDx's expanding EHR integration capabilities, providers will soon be able to order Prenatal Exome-to-Genome Reflex alongside our full prenatal testing portfolio directly within their EHR workflow.
To learn about EHR availability and ensure your organization has access to the latest GeneDx prenatal testing capabilities, connect with your GeneDx representative.
