Dried blood spot requirements

Dried blood spots specimen requirements

Dried blood spots (DBS) are accepted for certain tests in situations when drawing and shipping whole blood in liquid form is impractical. Whole blood specimens are always preferred because of restrictions imposed by the small specimen size of dried spots. DNA yield from some individuals may not be sufficient to complete testing. Refer to the test details page or the Alternate Specimen List for test availability.


Dried blood spots (DBS) is not accepted in the patient has ever received an allogeneic bone marrow/stem cell transplant. For patients who pursue genetic testing, DNA from cultured fibroblasts is the required specimen type. GeneDx can provide a punch biopsy kit and can culture fibroblasts on site, as needed.


For best results send 8 spots per person, of 10 mm diameter, completely filled. If 8 spots are not available, send as many as possible to reduce the chance of incomplete or delayed results. Minimum 2.


Label with the patient name, date of birth, and the medical record #.


The blood on the DBS cards should dry at room temperature for at least 3 hours after collection.


Dried blood spots will be rejected if submitted for any test for which DBS is not listed as an alternative specimen, if there is insufficient volume, or if the patient has had an allogeneic bone marrow transplant.


Ideal handling is to ship immediately, after drying, for overnight delivery with arrival Monday-Saturday.

Ship to
GeneDx, 207 Perry Parkway, Gaithersburg MD 20877
Phone: 1-301-519-2100