Lynch/Colorectal High Risk Panel

New York
Approved

Genes

APC, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2

Conditions

  • Colorectal Cancer
  • Familial Adenomatous Polyposis (FAP)
  • Lynch Syndrome
  • Attenuated Familial Adenomatous Polyposis (AFAP)

Clinical Utility

  • Colorectal or endometrial cancer diagnosed under 50 years of age
  • Multiple colon polyps (especially ≥ 20 adenomas) at any age
  • Tumor testing which indicates an increased risk for a hereditary cancer syndrome known as Lynch syndrome (e.g. microsatellite instability and/or lack of immunohistochemistry staining for a mismatch repair protein)
  • Multiple cancers in one person either of the same origin (such as two separate colorectal cancers) or of different origin (such as colon and endometrial cancer in the same individual)
  • Multiple relatives diagnosed with the same or related cancers (such as colon, endometrial, ovarian, urinary tract, gastric) on the same side of the family and spanning multiple generations

Lab Method

  • Deletion/Duplication Analysis
  • Next-Gen Sequencing

Test Code

B522

CPT Codes*

81201x1, 81203x1, 81403x1, 81406x1, 81292x1, 81294x1, 81295x1, 81297x1, 81298x1, 81300x1, 81317x1, 81319x1

ABN Required

No

Turnaround Time**

2 weeks

Preferred Specimen

2-5 mL Blood - Lavender Top Tube

Alternative Specimen

Buccal Swabs | Fibroblasts (separate charge for cell culture may apply)

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

**Turnaround times are estimates and begin once the sample(s) begin processing at the GeneDx lab and could be extended in situations outside GeneDx’s control.

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