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Cerebral Palsy Xpanded Panel

New York
Approved


Genes

AARS, AARS2, AASS, ABAT, ABCC8, ABCD1, ABHD12, ACAD9, ACADM, ACADVL, ACAT1, ACAT2, ACBD5, ACO2, ACOX1, ACP2, ACP5, ACSL4, ACTA1, ACTB, ACTG1, ACY1, ADAM22, ADAR, ADCY5, ADD3, ADGRG1, ADK, ADNP, ADRA2B, ADSL, AFG3L2, AGA, AHDC1, AHI1, AIFM1, AIMP1, AIMP2, AIP, AIPL1, AKT1, AKT3, ALDH18A1, ALDH3A2, ALDH5A1, ALDH6A1, ALDH7A1, ALG11, ALG13, ALG3, ALG6, ALS2, AMACR, AMMECR1, AMPD2, AMT, ANG, ANK3, ANKLE2, ANKRD11, ANO10, ANO3, AP1S2, AP3B2, AP3D1, AP4B1, AP4E1, AP4M1, AP4S1, AP5Z1, APOA1BP, APOPT1, APTX, ARCN1, ARFGEF2, ARG1, ARHGAP31, ARHGEF15, ARHGEF9, ARID1A, ARID1B, ARID2, ARL13B, ARL6IP1, ARMC9, ARNT2, ARSA, ARSI, ARSL (ARSE), ARV1, ARX, ASCC1, ASL, ASNS, ASPA, ASPM, ASS1, ASTN2, ASXL1, ASXL3, ATAD1, ATAD3A, ATAD3B, ATCAY, ATF4, ATIC, ATL1, ATM, ATP13A2, ATP1A2, ATP1A3, ATP2B3, ATP2B4, ATP5A1, ATP6AP2, ATP6V0A2, ATP6V1A, ATP6V1E1, ATP7A, ATP7B, ATP8A2, ATR, ATRX, AUH, AUTS2, B3GALNT2, B3GNT2, B4GALNT1, B4GAT1, B9D1, B9D2, BAZ1B, BCAP31, BCKDHA, BCKDHB, BCL11A, BCL11B, BCOR, BCS1L, BEAN1, BICD2, BMPER, BOLA3, BRAF, BRAT1, BTD, BSCL2, BUB1B, C10orf2, C11orf73, C12orf65, C19orf12, C19orf70, C21orf2, C2CD3, C5orf42, CA8, CACNA1A, CACNA1B, CACNA1D, CACNA1G, CACNA2D1, CACNA2D2, CAD, CALM1, CAMTA1, CAMTA2, CAPN1, CARS2, CASK, CASR, CAV1, CBS, CC2D1A, CC2D2A, CCBE1, CCDC22, CCDC88A, CCDC88C, CCND2, CCNF, CCT5, CDC42, CDK13, CDK5, CDK5RAP2, CDK6, CDKL5, CECR1, CENPE, CENPJ, CEP104, CEP120, CEP135, CEP152, CEP290, CEP41, CEP63, CHAMP1, CHAT, CHCHD10, CHD2, CHD4, CHD7, CHD8, CHEK2, CHMP1A, CHMP2B, CHN1, CHRNA1, CHRNA2, CHRNA4, CHRNA7, CHRNB2, CIT, CIZ1, CKAP2L, CLCN2, CLCN4, CLIC2, CLIP2, CLN3, CLN5, CLN6, CLN8, CLP1, CLPB, CLTC, CNKSR2, CNTNAP2, COA7, COASY, COG2, COG8, COL12A1, COL18A1, COL25A1, COL4A1, COL4A2, COL6A1, COL6A2, COL6A3, COLEC11, COQ2, COQ4, COQ6, COQ7, COQ8A, COQ9, COX10, COX15, CP, CPLX1, CPS1, CPT1A, CPT1C, CPT2, CRADD, CRB1, CREBBP, CRLF1, CRX, CSF1R, CSNK2A1, CSPP1, CSTB, CTBP1, CTC1, CTCF, CTDP1, CTNNB1, CTNND2, CTSB, CTSD, CTSF, CUL4B, CYB5R3, CYP27A1, CYP2U1, CYP7B1, D2HGDH, DAG1, DAO, DARS, DARS2, DBH, DBT, DCAF17, DCHS1, DCX, DDB2, DDC, DDHD1, DDHD2, DDX3X, DEAF1, DENND5A, DEPDC5, DGKZ, DGUOK, DHCR24, DHCR7, DHDDS, DHFR, DKC1, DKK1, DLAT, DLD, DLL4, DMD, DMXL2, DNAJC12, DNAJC3, DNAJC5, DNAJC6, DNASE1L3, DNM1, DNM1L, DNM2, DNMT1, DNMT3A, DOCK6, DOCK7, DPM3, DPYS, DRD2, DSTYK, DYNC1H1, DYRK1A, EARS2, EBF3, ECHS1, ECM1, EDNRB, EED, EEF1A2, EEF2, EFTUD2, EHMT1, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S3, ELAC2, ELN, ELOVL4, ELOVL5, ELP2, ELP4, EMC1, EML1, ENTPD1, EOGT, EP300, EPB41L4A, EPCAM, EPG5, EPHA4, EPM2A, ERBB4, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC8, ERLIN1, ERLIN2, ERMARD, ETFA, ETFB, ETFDH, ETHE1, EXOSC3, EXOSC8, EZH2, FA2H, FAAH, FADD, FAM126A, FAN1, FAR1, FARS2, FASN, FAT4, FBXL4, FBXO7, FGD1, FGF12, FGF14, FGFR1, FGFR2, FGFR3, FGFRL1, FH, FIG4, FITM2, FKRP, FKTN, FLI1, FLNA, FLRT1, FOLR1, FOXC1, FOXE1, FOXG1, FOXP1, FOXRED1, FRAS1, FREM2, FRRS1L, FTL, FTO, FUCA1, FUS, FXN, GABBR2, GABRA1, GABRA2, GABRB1, GABRB2, GABRB3, GABRG2, GAD1, GALC, GAMT, GAN, GATAD2B, GATM, GBA, GBA2, GBE1, GCDH, GCH1, GCK, GCSH, GDF6, GEMIN4, GFAP, GFM1, GFM2, GJA1, GJB1, GJC2, GLB1, GLDC, GLE1, GLI2, GLI3, GLRA1, GLRB, GLRX5, GLUL, GLYCTK, GM2A, GMPPB, GNA11, GNAL, GNAO1, GNAS, GNB1, GOSR2, GPBP1, GPC3, GPHN, GPR101, GPR35, GPR88, GPSM2, GPT2, GPX4, GRIA3, GRID2, GRIK2, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIP1, GSS, GTF2IRD1, GTPBP3, GUCY2D, GUF1, HACE1, HADH, HCFC1, HCN1, HDAC8, HECW2, HEPACAM, HERC1, HESX1, HEXA, HIBCH, HIC1, HIST1H1E, HIVEP2, HLCS, HMGCL, HNMT, HNRNPA1, HNRNPH2, HNRNPU, HPCA, HPGD, HPRT1, HSD17B10, HSD17B4, HSPD1, HSPG2, HTRA1, HTRA2, HUWE1, HYLS1, IARS, IBA57, IDH1, IDH2, IDH3A, IDS, IDUA, IER3IP1, IFIH1, IFT140, IFT172, IL1RAPL1, IL6, IMPDH1, INPP4A, INPP5E, INPP5K, INS, IQCB1, IQSEC2, ISCA2, ISPD, ITM2B, ITPA, ITPR1, JAM3, KANK1, KANSL1, KARS, KAT6A, KAT6B, KATNB1, KCNA1, KCNA2, KCNAB1, KCNB1, KCNC1, KCNC3, KCND3, KCNE1L(KCNE5), KCNH1, KCNJ10, KCNJ11, KCNJ6, KCNMA1, KCNQ2, KCNQ3, KCNQ5, KCNT1, KCTD17, KCTD7, KDM5A, KDM5C, KDM6A, KIAA0196, KIAA0556, KIAA0586, KIAA1033, KIAA1279, KIAA2022 (NEXMIF), KIDINS220, KIF11, KIF1A, KIF1C, KIF2A, KIF5A, KIF7, KLC2, KLC4, KLF13, KLHL15, KMT2A (MLL), KMT2B, KMT2C, KMT2D, KNL1, KRAS, KY, KYNU, L1CAM, L2HGDH, LAGE3, LAMA1, LAMA2, LAMB1, LAMC3, LARGE, LARP7, LCA5, LETM1, LGI1, LIAS, LIMK1, LIPT1, LIPT2, LMAN2L, LMBRD1, LMNB1, LMNB2, LRAT, LRFN2, LYRM7, MAFB, MAG, MAGI2, MAN2B1, MAOA, MAP2K1, MAP3K12, MAPK10, MARS, MARS2, MAST1, MAT1A, MATR3, MBD5, MBOAT7, MBTPS2, MCCC1, MCCC2, MCEE, MCOLN1, MCPH1, MDH2, MDM2, MECP2, MECR, MED12, MED13L, MED17, MED25, MEF2C, MFF, MFN2, MFSD2A, MFSD8, MGAT2, MICU1, MICU2, MKS1, MLC1, MLH3, MLYCD, MMAA, MMAB, MMACHC, MMADHC, MME, MOCS1, MOCS2, MOCS3, MPC1, MPDZ, MPV17, MPZ, MR1, MRE11A, MRPS22, MST1, MTFMT, MTHFR, MTO1, MTOR, MTPAP, MTR, MTRR, MTTP, MUT, MYO5A, MYT1L, NAA10, NACC1, NADK2, NAGA, NAGPA, NAGS, NALCN, NANS, NARS2, NBAS, NBN, NDE1, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFB3, NDUFB9, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NF1, NECAP1, NEDD4L, NEFH, NEK1, NELFA, NFIX, NFU1, NGLY1, NHLRC1, NIN, NIPA1, NIPBL, NKAIN2, NKX2-1, NKX2-5, NKX6-2, NMNAT1, NOTCH1, NOTCH3, NPC1, NPC2, NPHP1, NPHP3, NPRL3, NR2F1, NR4A2, NRXN1, NSD1, NSDHL, NSUN2, NT5C2, NTNG1, NTRK2, NUBPL, NUP107, NUP62, NUS1, OBFC1, OCLN, OCRL, OFD1, OPA1, OPA3, OPHN1, OPTN, OSGEP, OTC, OTUD6B, PACS1, PAFAH1B1, PAH, PAK3, PALM, PANK2, PARK7, PARS2, PAX3, PAX6, PAX8, PC, PCBD1, PCCA, PCCB, PCDH12, PCDH19, PCLO, PCYT1A, PDC, PDE10A, PDE2A, PDGFB, PDGFRB, PDHA1, PDHB, PDHX, PDP1, PDSS1, PDSS2, PDX1, PDYN, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PFN1, PGAP1, PGAP2, PHC1, PHF6, PHGDH, PHIP, PHKA1, PHYH, PIGA, PIGG, PIGN, PIGO, PIGP, PIGV, PIK3CA, PIK3R2, PINK1, PLA2G6, PLAA, PLCB1, PLEKHG2, PLK4, PLP1, PLXNA2, PMP22, PMPCA, PMS1, PNKD, PNKP, PNP, PNPLA6, PNPLA8, PNPO, PNPT1, POGZ, POLA1, POLG, POLR1C, POLR1D, POLR3A, POLR3B, POMGNT1, POMGNT2, POMK, POMT1, POMT2, PON1, PON2, PON3, PPARGC1A, PPM1D, PPP1R15B, PPP2R1A, PPP2R5D, PPP3CA, PPT1, PQBP1, PRDM8, PRICKLE1, PRKCG, PRKDC, PRKRA, PROSC, PRPH, PRRT2, PRUNE, PSAP, PSAT1, PSPH, PTCHD1, PTEN, PTPN11, PTPN23, PTS, PURA, PUS3, PYCR2, QARS, QDPR, QKI, RAB11A, RAB12, RAB18, RAB27A, RAB3GAP1, RAB3GAP2, RAD21, RAD50, RAG1, RAI1, RANBP2, RARS2, RAX, RBPJ, RD3, RDH12, RECQL4, REEP1, REEP2, RELN, FAM134B, RFC2, RFT1, RIT1, RMND1, RNASEH2A, RNASEH2B, RNASEH2C, RNASET2, RNF113A, RNF125, RNF216, ROGDI, RPE65, RPGRIP1, RPGRIP1L, RPIA, RPS6KA3, RRM2B, RSPH4A, RTN2, RTN4IP1, RTTN, SACS, SAMHD1, SARS2, SASS6, SATB2, SCARB2, SCN10A, SCN1A, SCN1B, SCN2A, SCN3A, SCN4A, SCN8A, SCO1, SCP2, SCYL1, SDHA, SDHAF1, SDHB, SDHD, SEMA5A, SEPSECS, SERAC1, SETBP1, SETD2, SETD5, SETX, SF3B4, SGCE, SH2D1A, SHANK3, SHH, SHOC2, SHROOM4, SIGMAR1, SIK1, SIL1, SIN3A, SIX3, SIX6, SLC12A5, SLC13A5, SLC16A2, SLC17A5, SLC18A2, SLC19A3, SLC1A2, SLC1A4, SLC20A2, SLC22A5, SLC25A1, SLC25A12, SLC25A15, SLC25A19, SLC25A20, SLC25A22, SLC26A1, SLC26A4, SLC2A1, SLC2A3, SLC30A10, SLC33A1, SLC35A2, SLC35A3, SLC35C1, SLC39A14, SLC39A8, SLC46A1, SLC6A1, SLC6A17, SLC6A19, SLC6A3, SLC6A5, SLC6A8, SLC6A9, SLC7A2, SLC9A1, SLC9A6, SLCO2A1, SMARCA2, SMARCA4, SMARCB1, SMC1A, SMC3, SMO, SMOC1, SMPD1, SNAP25, SNAP29, SNCA, SNCAIP, SNX14, SOBP, SOD1, SON, SOS1, SOX10, SOX2, SOX6, SPAST, SPATA5, SPATA7, SPG11, SPG20, SPG21, SPG7, SPR, SPTAN1, SPTBN2, SQSTM1, SRD5A3, SRPX2, SSR4, ST3GAL5, STAMBP, STAT1, STAT2, STAT3, STIL, STRA6, STS, STUB1, STX16, STX1B, STXBP1, SUCLA2, SUCLG1, SUMF1, SUOX, SURF1, SUZ12, SYNE1, SYNGAP1, SYNJ1, SYT14, SYT2, SZT2, TAF1, TAF13, TAF15, TAF2, TANGO2, TARDBP, TARS2, TBC1D20, TBC1D24, TBCD, TBCE, TBCK, TBK1, TBL1XR1, TBL2, TCF4, TCOF1, TCTN1, TCTN2, TCTN3, TECPR2, TELO2, TENM1, TFG, TGIF1, TGM6, TH, THAP1, TIMM50, TIMM8A, TIMMDC1, TK2, TMEM126B, TMEM138, TMEM216, TMEM231, TMEM237, TMEM240, TMEM5, TMEM67, TMEM70, TMTC3, TNR, TOE1, TOPORS, TOR1A, TOR1AIP1, TP53RK, TPI1, TPK1, TPP1, TPRKB, TRAIP, TRAK1, TRAPPC11, TRAPPC12, TRAPPC9, TREX1, TRIM8, TRIO, TRIP12, TRIT1, TRMT5, TRPV4, TSEN15, TSEN2, TSEN34, TSEN54, TSFM, TSHB, TSHR, TTBK2, TTC19, TTC21B, TTF1, TTPA, TTR, TUBA1A, TUBA8, TUBB, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBG1, TUBGCP4, TUBGCP6, TUFM, TULP1, TWIST1, TXN2, TYMP, TYROBP, UBA5, UBB, UBE3A, UBQLN2, UCHL1, UNC13A, UNC80, UPB1, UPF3B, UQCRQ, UROC1, USP18, USP8, USP9X, VAC14, VAMP1, VAPB, VARS2, VCP, VIPAS39, VLDLR, VPS11, VPS13A, VPS13C, VPS16, VPS33B, VPS37A, VPS53, VRK1, VWA3B, WAC, WARS2, WDR26, WDR45, WDR48, WDR62, WDR73, WDR81, WHSC1, WWOX, XIAP, XPA, XPR1, XRCC4, YME1L1, YWHAE, YWHAG, YY1, ZBTB18, ZC4H2, ZDHHC15, ZDHHC9, ZEB2, ZFR, ZFYVE26, ZFYVE27, ZIC1, ZIC2, ZNF335, ZNF423, ZNF592, ZNHIT3

Conditions

  • Cerebral Palsy

Clinical Utility

  • Molecular confirmation of a clinical diagnosis
  • Identification of at-risk family members
  • Assist with treatment/ management decisions
  • Recurrence risk assessment
  • Prenatal diagnosis for known familial pathogenic variant(s) in at-risk pregnancies

Lab Method

  • Next-Gen Sequencing

Test Code

T851

CPT Codes*

81185x1, 81302x1, 81404x1, 81405x2, 81406x2, 81408x1

ABN Required

No

Turnaround Time**

6 weeks

Preferred Specimen

2-5 mL Blood - Lavender Top Tube

Alternative Specimen

Buccal Swabs

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

**Reporting times are typical and begin once the sample(s) are received at the GeneDx laboratory, but could be extended in situations outside GeneDx’s reasonable control.