Velocardiofacial syndrome (VCFS) and DiGeorge syndrome (DGS) are well-characterized syndromes with multisystem involvement, dysmorphic facial features, and cognitive disabilities. A range of systemic findings may include congenital heart defects, which are present in 75% of individuals (conotruncal malformations, interrupted aortic arch, ventricular/atrial septal defects and teratology of fallot), palatal defects seen in 69% of individuals (velopharyngeal incompetence (VPI), submucosal cleft palate and cleft palate), and immune deficiencies secondary to thymic hypoplasia seen in up to 77% of individuals. Typical facial features include a long face, small almond shaped eyes, a wide bridged nose, and malformations of the ear. Learning disabilities, including delayed speech and developmental milestones, are present in 70-90% of individuals. Additional findings may include hypocalcemia (most severe during the neonatal period), feeding problems, psychiatric illness, seizures, renal abnormalities, short stature, hypotonia, scoliosis, and tapered fingers. Atypical features include autoimmune diseases (thrombocytopenia, juvenile rheumatoid arthritis, and vitiligo), hearing loss, and growth hormone deficiencies.