Pheochromocytoma

Forms and Documents

Test Details

  • Confirmation of a clinical diagnosis
  • Carrier testing
  • Prenatal diagnosis in at risk pregnancies

Ordering

582
4 weeks
2-5 mL Blood - Lavender Top Tube
Buccal Swabs

Billing

81406x1
No
Yes
For price inquiries please email zebras@genedx.com

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

References

  1. Parfait (2000) Hum Genet 106: 236.
  2. Horvath (2006) J Neurol Neurosurg Psychiatry 77:74.
  3. Bourgeron (1995) Nat Genet 11:144.
  4. Birch-Machin (2000) Ann Neurol 48:330.
  5. Van Coster (2003) Am J Med Genet 120A:13.
  6. Levitas (2010) Eur J Hum Genet 18: 1160.
  7. Burnichon (2010) Hum Mol Genet 19:3011.

Forms and Documents

Test Details

FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL
  • A personal and/or family history of one or more paragangliomas or pheochromocytomas
  • A pattern of cancer in which individuals with similar or related cancers (see table below) are on one side of the family and spanning multiple generations

Ordering

B395
3 weeks
2-5 mL Blood - Lavender Top Tube
Buccal Swabs | Fibroblasts (separate charge for cell culture may apply)

Billing

81403x1, 81404x3, 81405x2
Yes
Yes
For price inquiries please email zebras@genedx.com

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

References

  1. American Thyroid et al. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid. 2009 Jun;19(6):565-612.
  2. Bryant J et al. Pheochromocytoma: the expanding genetic differential diagnosis. J Natl Cancer Inst. 2003 Aug 20;95(16):1196-204. (PMID: 12928344)
  3. Coughlin EM et al. Molecular analysis and prenatal diagnosis of human fumarase deficiency. Mol Genet Metab. 1998 Apr;63(4):254-62.9635293 (PMID: 9635293)
  4. Friedman JM. Neurofibromatosis 1. 1998 Oct 2 [Updated 2014 Sep 4]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/
  5. Gellera C et al. Fumarase deficiency is an autosomal recessive encephalopathy affecting both the mitochondrial and the cytosolic enzymes. Neurology. 1990 Mar;40(3 Pt 1):495-9. 2314594 (PMID: 2314594)
  6. Kirmani S and Young WF. Hereditary Paraganglioma-Pheochromocytoma Syndromes. 2008 May 21 [Updated 2014 Nov 6]. In: Pagon RA, Bird TD, Dolan CR, et al., editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-. Available from
  7. Lenders JW et al. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. The Journal Of Clinical Endocrinology And Metabolism. 2014 Jun;99(6):1915-42. (PMID: 24893135)
  8. Menko FH et al. Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment. Fam Cancer. 2014 Dec;13(4):637-44. (PMID: 25012257)
  9. Mroch AR et al. Detection of a novel FH whole gene deletion in the propositus leading to subsequent prenatal diagnosis in a sibship with fumarase deficiency. Am J Med Genet A. 2012 Jan;158A(1):155-8. (PMID: 22069215)
  10. NCCN Guidelines. Thyroid Carcinoma. Version 2.2015 (URL: http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf) November 2015 accessed.
  11. Thakker et al. Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1). The Journal of Clinical Endocrinology and Metabolism. 2012;97(9):2990-3011. (PMID: 22723327)

Forms and Documents

CREATE A CUSTOM PANEL

Test Details

  • Identify the genetic basis of cancer for individuals who have features and/or a family history consistent with one of the hereditary cancer syndromes described above.
  • Determine appropriate clinical management recommendations based on a molecular diagnosis.
  • Identify family members at-risk to develop features associated with a specific hereditary cancer syndrome.

Ordering

B749
21 days
2-5 mL Blood - Lavender Top Tube
Buccal Swabs | Fibroblasts (separate charge for cell culture may apply)

Billing

Varies by Gene
Yes
Yes
For price inquiries please email zebras@genedx.com

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Forms and Documents

Test Details

A2ML1, ABCB7, ABL1, ABL2, ACBD5, ACD, AIP, AK2, AKR1C4, AKT1, AKT2, AKT3, ALAS2, ALK, ANKRD26, AP2S1, AP3B1, APAF1, APC, APPL1, ARAF, ARHGEF12, ARID1A, ARID2, ARNT, ASCC1, ASXL1, ATG2B, ATM, ATP4A, ATR, ATRIP, AXIN1, AXIN2, BAP1, BARD1, BAX, BBC3, BCL10, BCL2L1, BCL6, BCR, BDNF, BID, BIRC5, BLM, BMP1, BMP2, BMP4, BMPR1A, BRAF, BRCA1, BRCA2, BRIP1, BTK, BUB1, BUB1B, BUB3, C15ORF41, CAMTA1, CARD11, CASP3, CASP8, CASP9, CASR, CBFA2T3, CBL, CBX8, CCDC18, CCNA1, CCNB2, CCND1, CCND2, CCNE1, CD27, CD274, CD40LG, CDAN1, CDC42, CDC73, CDH1, CDH11, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CEBPA, CEP164, CEP57, CHAD, CHD8, CHEK1, CHEK2, CLCA2, CLPB, COQ6, CREBBP, CSF3R, CTBP1, CTC1, CTHRC1, CTNNA1, CTNNB1, CTR9, CUL2, CUL4B, CXCL8, CXCR4, CYLD, DCLRE1B, DDB1, DDB2, DDX41, DICER1, DIS3L2, DKC1, DNAJC21, DNMT3A, DOT1L, DUSP10, DUSP4, DUT, E2F3, EGF, EGFR, EGLN1, EGLN2, EIF2AK4, EIF3H, ELAC2, ELANE, ENG, EP300, EPAS1, EPCAM, EPHB2, EPHX1, EPO, ERBB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L2, ERCC8, ESR1, ETV6, EXT1, EXT2, EZH2, FAH, FAM175A, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FASN, FBXO24, FBXW7, FCGR2A, FGFR1, FGFR2, FGFR3, FH, FHIT, FLCN, FLT3, FOCAD, FOS, FOXE1, FOXO1, FOXO3, FOXO4, FOXP1, G6PC3, GALNT12, GATA1, GATA2, GEN1, GFI1, GLI1, GLI3, GLRX5, GMPS, GNA11, GNE, GP1BA, GPC3, GREM1, GSK3B, GSKIP, GSTP1, HABP2, HAUS3, HAVCR2, HAX1, HCCS, HEPACAM, HERC1, HGF, HIF1A, HIP1, HLTF, HMBS, HNF1A, HNF1B, HOXA11, HOXB13, HRAS, IDH1, IDH2, IGF1R, IKBKB, IL12RB1, IL2RA, IL6, IPMK, ITGA3, ITGB1, ITK, JAGN1, JAK1, JAK2, JAK3, JUN, KDM3B, KDR, KIF1B, KIF23, KIT, KITLG, KLF1, KLF6, KLK3, KRAS, LAMA5, LAMC1, LAMTOR2, LATS1, LATS2, LCK, LHCGR, LIG3, LIG4, LIMK2, LMO1, LRIG3, LYST, LZTR1, MAD2L2, MAF, MAFB, MAP2K1, MAP2K2, MAP2K4, MAP2K5, MAP3K1, MAP3K4, MAP3K6, MAP4K2, MAPK1, MAPK3, MAPKAP1, MASTL, MAX, MBD4, MC1R, MCM4, MDH2, MDM2, MECOM, MED12, MEN1, MET, MGMT, MITF, MLH1, MLH3, MN1, MPL, MRAS, MRE11A, MRPL3, MS4A1, MSH2, MSH3, MSH6, MSMB, MSR1, MST1, MTAP, MTOR, MUC1, MUTYH, MYC, MYCN, MYH8, MYH9, NABP1, NAT1, NBN, NCOA4, NDRG1, NDRG4, NDUFA13, NF1, NF2, NFIA, NFIX, NFKB1, NFKBIZ, NHP2, NKX2-1, NKX3-1, NLRP1, NLRP7, NOP10, NOS2, NOTCH1, NOTCH3, NPAT, NPM1, NR4A3, NR5A2, NRAS, NSD1, NTHL1, NTRK1, NTRK3, NUDT15, NUDT7, OBFC1, OCA2, OFD1, OGG1, OR5H14, PALB2, PALLD, PARN, PARP1, PAX2, PAX5, PBRM1, PCK2, PDE8B, PDGFB, PDGFRA, PDGFRB, PGM3, PGR, PHF6, PHOX2B, PIEZO1, PIF1, PIK3CA, PIK3R2, PITX1, PITX3, PKD1, PLAU, PLCB1, PLCG1, PLD1, PML, PMS1, PMS2, PNP, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLH, POT1, PPARG, PPM1D, PPP1CB, PPP2R5D, PRADC1, PRF1, PRKACA, PRKACB, PRKAR1A, PRKDC, PROM1, PRSS37, PSPH, PTCH1, PTCH2, PTCHD2, PTEN, PTGS2, PTK2, PTPN11, PUS1, RAB27A, RAB39B, RAB5B, RABL3, RAC1, RAC2, RAD17, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RALBP1, RALGDS, RARB, RASA1, RASA2, RASAL1, RASGEF1A, RASSF1, RASSF5, RB1, RBBP6, RBBP8, RBL1, RBL2, RBM8A, RECQL, RECQL4, REST, RET, RFC1, RFWD3, RHBDF2, RINT1, RIT1, RMI2, RNASEL, RNF135, RNF139, RNF168, RNF43, ROCK1, ROS1, RPL10, RPL11, RPL15, RPL19, RPL26, RPL27, RPL31, RPL35, RPL35A, RPL5, RPL9, RPS10, RPS15A, RPS17, RPS19, RPS20, RPS24, RPS26, RPS27, RPS28, RPS29, RPS7, RRAS, RTEL1, RUNX1, SAMD9, SAMD9L, SASH1, SBDS, SBF2, SDHA, SDHAF2, SDHB, SDHC, SDHD, SEC14L3, SEC23B, SERPINA7, SETBP1, SETD2, SFTPA2, SH2B3, SH2D1A, SHC1, SHOC2, SKP2, SLC19A2, SLC25A11, SLC25A38, SLC35C1, SLC37A4, SLC5A5, SLC5A9, SLX4, SMAD4, SMAD7, SMARCA4, SMARCB1, SMARCE1, SMO, SNX14, SOCS1, SOS1, SOS2, SPI1, SPRED1, SRGAP1, SRP54, SRP72, SRRM2, STAT4, STAT5A, STK11, STX11, STXBP2, SUFU, SYK, T, TAZ, TBC1D7, TCEB1, TCEB2, TCF7, TCF7L2, TCIRG1, TELO2, TERC, TERF2, TERF2IP, TERT, TET2, TFE3, TG, TGFA, THPO, TINF2, TMC6, TMC8, TMEM127, TNFRSF10B, TP53, TP53BP1, TPMT, TRIM24, TRIM28, TRIP13, TRNT1, TSC1, TSC2, TSHR, TSR2, TWSG1, TYK2, UACA, UBE2T, ULK4, UNC13D, UPF3B, USB1, VHL, VPS13B, VPS45, WAS, WIF1, WIPF1, WNT1, WNT10A, WNT10B, WNT3A, WNT7A, WNT8A, WRAP53, WRN, WT1, WWOX, XAF1, XIAP, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, XRCC6, YAP1, YARS2, ZBTB16, ZFHX4, ZSWIM7
  • Molecular confirmation of a clinical diagnosis
  • Identify the genetic basis of cancer for individuals who have features and/or a family history consistent with a hereditary cancer syndrome
  • To assist with decisions about treatment and clinical management of individuals with cancer
  • Identify family members at-risk to develop features associated with a specific hereditary cancer syndrome

**ATTENTION**
The Xpanded HereditaryCancer Panel performed on a singleton (proband only).

Ordering

TH42a
6 weeks
2-5 mL Blood - Lavender Top Tube
Buccal Swabs | Dried Blood Spots

Billing

81415x1
No
No
For price inquiries please email zebras@genedx.com

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Forms and Documents

Test Details

A2ML1, ABCB7, ABL1, ABL2, ACBD5, ACD, AIP, AK2, AKR1C4, AKT1, AKT2, AKT3, ALAS2, ALK, ANKRD26, AP2S1, AP3B1, APAF1, APC, APPL1, ARAF, ARHGEF12, ARID1A, ARID2, ARNT, ASCC1, ASXL1, ATG2B, ATM, ATP4A, ATR, ATRIP, AXIN1, AXIN2, BAP1, BARD1, BAX, BBC3, BCL10, BCL2L1, BCL6, BCR, BDNF, BID, BIRC5, BLM, BMP1, BMP2, BMP4, BMPR1A, BRAF, BRCA1, BRCA2, BRIP1, BTK, BUB1, BUB1B, BUB3, C15ORF41, CAMTA1, CARD11, CASP3, CASP8, CASP9, CASR, CBFA2T3, CBL, CBX8, CCDC18, CCNA1, CCNB2, CCND1, CCND2, CCNE1, CD27, CD274, CD40LG, CDAN1, CDC42, CDC73, CDH1, CDH11, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CEBPA, CEP164, CEP57, CHAD, CHD8, CHEK1, CHEK2, CLCA2, CLPB, COQ6, CREBBP, CSF3R, CTBP1, CTC1, CTHRC1, CTNNA1, CTNNB1, CTR9, CUL2, CUL4B, CXCL8, CXCR4, CYLD, DCLRE1B, DDB1, DDB2, DDX41, DICER1, DIS3L2, DKC1, DNAJC21, DNMT3A, DOT1L, DUSP10, DUSP4, DUT, E2F3, EGF, EGFR, EGLN1, EGLN2, EIF2AK4, EIF3H, ELAC2, ELANE, ENG, EP300, EPAS1, EPCAM, EPHB2, EPHX1, EPO, ERBB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L2, ERCC8, ESR1, ETV6, EXT1, EXT2, EZH2, FAH, FAM175A, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FASN, FBXO24, FBXW7, FCGR2A, FGFR1, FGFR2, FGFR3, FH, FHIT, FLCN, FLT3, FOCAD, FOS, FOXE1, FOXO1, FOXO3, FOXO4, FOXP1, G6PC3, GALNT12, GATA1, GATA2, GEN1, GFI1, GLI1, GLI3, GLRX5, GMPS, GNA11, GNE, GP1BA, GPC3, GREM1, GSK3B, GSKIP, GSTP1, HABP2, HAUS3, HAVCR2, HAX1, HCCS, HEPACAM, HERC1, HGF, HIF1A, HIP1, HLTF, HMBS, HNF1A, HNF1B, HOXA11, HOXB13, HRAS, IDH1, IDH2, IGF1R, IKBKB, IL12RB1, IL2RA, IL6, IPMK, ITGA3, ITGB1, ITK, JAGN1, JAK1, JAK2, JAK3, JUN, KDM3B, KDR, KIF1B, KIF23, KIT, KITLG, KLF1, KLF6, KLK3, KRAS, LAMA5, LAMC1, LAMTOR2, LATS1, LATS2, LCK, LHCGR, LIG3, LIG4, LIMK2, LMO1, LRIG3, LYST, LZTR1, MAD2L2, MAF, MAFB, MAP2K1, MAP2K2, MAP2K4, MAP2K5, MAP3K1, MAP3K4, MAP3K6, MAP4K2, MAPK1, MAPK3, MAPKAP1, MASTL, MAX, MBD4, MC1R, MCM4, MDH2, MDM2, MECOM, MED12, MEN1, MET, MGMT, MITF, MLH1, MLH3, MN1, MPL, MRAS, MRE11A, MRPL3, MS4A1, MSH2, MSH3, MSH6, MSMB, MSR1, MST1, MTAP, MTOR, MUC1, MUTYH, MYC, MYCN, MYH8, MYH9, NABP1, NAT1, NBN, NCOA4, NDRG1, NDRG4, NDUFA13, NF1, NF2, NFIA, NFIX, NFKB1, NFKBIZ, NHP2, NKX2-1, NKX3-1, NLRP1, NLRP7, NOP10, NOS2, NOTCH1, NOTCH3, NPAT, NPM1, NR4A3, NR5A2, NRAS, NSD1, NTHL1, NTRK1, NTRK3, NUDT15, NUDT7, OBFC1, OCA2, OFD1, OGG1, OR5H14, PALB2, PALLD, PARN, PARP1, PAX2, PAX5, PBRM1, PCK2, PDE8B, PDGFB, PDGFRA, PDGFRB, PGM3, PGR, PHF6, PHOX2B, PIEZO1, PIF1, PIK3CA, PIK3R2, PITX1, PITX3, PKD1, PLAU, PLCB1, PLCG1, PLD1, PML, PMS1, PMS2, PNP, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLH, POT1, PPARG, PPM1D, PPP1CB, PPP2R5D, PRADC1, PRF1, PRKACA, PRKACB, PRKAR1A, PRKDC, PROM1, PRSS37, PSPH, PTCH1, PTCH2, PTCHD2, PTEN, PTGS2, PTK2, PTPN11, PUS1, RAB27A, RAB39B, RAB5B, RABL3, RAC1, RAC2, RAD17, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RALBP1, RALGDS, RARB, RASA1, RASA2, RASAL1, RASGEF1A, RASSF1, RASSF5, RB1, RBBP6, RBBP8, RBL1, RBL2, RBM8A, RECQL, RECQL4, REST, RET, RFC1, RFWD3, RHBDF2, RINT1, RIT1, RMI2, RNASEL, RNF135, RNF139, RNF168, RNF43, ROCK1, ROS1, RPL10, RPL11, RPL15, RPL19, RPL26, RPL27, RPL31, RPL35, RPL35A, RPL5, RPL9, RPS10, RPS15A, RPS17, RPS19, RPS20, RPS24, RPS26, RPS27, RPS28, RPS29, RPS7, RRAS, RTEL1, RUNX1, SAMD9, SAMD9L, SASH1, SBDS, SBF2, SDHA, SDHAF2, SDHB, SDHC, SDHD, SEC14L3, SEC23B, SERPINA7, SETBP1, SETD2, SFTPA2, SH2B3, SH2D1A, SHC1, SHOC2, SKP2, SLC19A2, SLC25A11, SLC25A38, SLC35C1, SLC37A4, SLC5A5, SLC5A9, SLX4, SMAD4, SMAD7, SMARCA4, SMARCB1, SMARCE1, SMO, SNX14, SOCS1, SOS1, SOS2, SPI1, SPRED1, SRGAP1, SRP54, SRP72, SRRM2, STAT4, STAT5A, STK11, STX11, STXBP2, SUFU, SYK, T, TAZ, TBC1D7, TCEB1, TCEB2, TCF7, TCF7L2, TCIRG1, TELO2, TERC, TERF2, TERF2IP, TERT, TET2, TFE3, TG, TGFA, THPO, TINF2, TMC6, TMC8, TMEM127, TNFRSF10B, TP53, TP53BP1, TPMT, TRIM24, TRIM28, TRIP13, TRNT1, TSC1, TSC2, TSHR, TSR2, TWSG1, TYK2, UACA, UBE2T, ULK4, UNC13D, UPF3B, USB1, VHL, VPS13B, VPS45, WAS, WIF1, WIPF1, WNT1, WNT10A, WNT10B, WNT3A, WNT7A, WNT8A, WRAP53, WRN, WT1, WWOX, XAF1, XIAP, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, XRCC6, YAP1, YARS2, ZBTB16, ZFHX4, ZSWIM7
  • Molecular confirmation of a clinical diagnosis
  • Identify the genetic basis of cancer for individuals who have features and/or a family history consistent with a hereditary cancer syndrome
  • To assist with decisions about treatment and clinical management of individuals with cancer
  • Identify family members at-risk to develop features associated with a specific hereditary cancer syndrome

**ATTENTION**
The Xpanded HereditaryCancer Panel will use a trio approach that includes concurrent analysis of the affected proband and both parents or other relatives.

Ordering

TH42b
6 weeks
2-5 mL Blood - Lavender Top Tube
Buccal Swabs | Dried Blood Spots

Billing

81415x1
No
No
For price inquiries please email zebras@genedx.com

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Forms and Documents

Test Details

A2ML1, ABCB7, ABL1, ABL2, ACBD5, ACD, AIP, AK2, AKR1C4, AKT1, AKT2, AKT3, ALAS2, ALK, ANKRD26, AP2S1, AP3B1, APAF1, APC, APPL1, ARAF, ARHGEF12, ARID1A, ARID2, ARNT, ASCC1, ASXL1, ATG2B, ATM, ATP4A, ATR, ATRIP, AXIN1, AXIN2, BAP1, BARD1, BAX, BBC3, BCL10, BCL2L1, BCL6, BCR, BDNF, BID, BIRC5, BLM, BMP1, BMP2, BMP4, BMPR1A, BRAF, BRCA1, BRCA2, BRIP1, BTK, BUB1, BUB1B, BUB3, C15ORF41, CAMTA1, CARD11, CASP3, CASP8, CASP9, CASR, CBFA2T3, CBL, CBX8, CCDC18, CCNA1, CCNB2, CCND1, CCND2, CCNE1, CD27, CD274, CD40LG, CDAN1, CDC42, CDC73, CDH1, CDH11, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CEBPA, CEP164, CEP57, CHAD, CHD8, CHEK1, CHEK2, CLCA2, CLPB, COQ6, CREBBP, CSF3R, CTBP1, CTC1, CTHRC1, CTNNA1, CTNNB1, CTR9, CUL2, CUL4B, CXCL8, CXCR4, CYLD, DCLRE1B, DDB1, DDB2, DDX41, DICER1, DIS3L2, DKC1, DNAJC21, DNMT3A, DOT1L, DUSP10, DUSP4, DUT, E2F3, EGF, EGFR, EGLN1, EGLN2, EIF2AK4, EIF3H, ELAC2, ELANE, ENG, EP300, EPAS1, EPCAM, EPHB2, EPHX1, EPO, ERBB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L2, ERCC8, ESR1, ETV6, EXT1, EXT2, EZH2, FAH, FAM175A, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FASN, FBXO24, FBXW7, FCGR2A, FGFR1, FGFR2, FGFR3, FH, FHIT, FLCN, FLT3, FOCAD, FOS, FOXE1, FOXO1, FOXO3, FOXO4, FOXP1, G6PC3, GALNT12, GATA1, GATA2, GEN1, GFI1, GLI1, GLI3, GLRX5, GMPS, GNA11, GNE, GP1BA, GPC3, GREM1, GSK3B, GSKIP, GSTP1, HABP2, HAUS3, HAVCR2, HAX1, HCCS, HEPACAM, HERC1, HGF, HIF1A, HIP1, HLTF, HMBS, HNF1A, HNF1B, HOXA11, HOXB13, HRAS, IDH1, IDH2, IGF1R, IKBKB, IL12RB1, IL2RA, IL6, IPMK, ITGA3, ITGB1, ITK, JAGN1, JAK1, JAK2, JAK3, JUN, KDM3B, KDR, KIF1B, KIF23, KIT, KITLG, KLF1, KLF6, KLK3, KRAS, LAMA5, LAMC1, LAMTOR2, LATS1, LATS2, LCK, LHCGR, LIG3, LIG4, LIMK2, LMO1, LRIG3, LYST, LZTR1, MAD2L2, MAF, MAFB, MAP2K1, MAP2K2, MAP2K4, MAP2K5, MAP3K1, MAP3K4, MAP3K6, MAP4K2, MAPK1, MAPK3, MAPKAP1, MASTL, MAX, MBD4, MC1R, MCM4, MDH2, MDM2, MECOM, MED12, MEN1, MET, MGMT, MITF, MLH1, MLH3, MN1, MPL, MRAS, MRE11A, MRPL3, MS4A1, MSH2, MSH3, MSH6, MSMB, MSR1, MST1, MTAP, MTOR, MUC1, MUTYH, MYC, MYCN, MYH8, MYH9, NABP1, NAT1, NBN, NCOA4, NDRG1, NDRG4, NDUFA13, NF1, NF2, NFIA, NFIX, NFKB1, NFKBIZ, NHP2, NKX2-1, NKX3-1, NLRP1, NLRP7, NOP10, NOS2, NOTCH1, NOTCH3, NPAT, NPM1, NR4A3, NR5A2, NRAS, NSD1, NTHL1, NTRK1, NTRK3, NUDT15, NUDT7, OBFC1, OCA2, OFD1, OGG1, OR5H14, PALB2, PALLD, PARN, PARP1, PAX2, PAX5, PBRM1, PCK2, PDE8B, PDGFB, PDGFRA, PDGFRB, PGM3, PGR, PHF6, PHOX2B, PIEZO1, PIF1, PIK3CA, PIK3R2, PITX1, PITX3, PKD1, PLAU, PLCB1, PLCG1, PLD1, PML, PMS1, PMS2, PNP, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLH, POT1, PPARG, PPM1D, PPP1CB, PPP2R5D, PRADC1, PRF1, PRKACA, PRKACB, PRKAR1A, PRKDC, PROM1, PRSS37, PSPH, PTCH1, PTCH2, PTCHD2, PTEN, PTGS2, PTK2, PTPN11, PUS1, RAB27A, RAB39B, RAB5B, RABL3, RAC1, RAC2, RAD17, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RALBP1, RALGDS, RARB, RASA1, RASA2, RASAL1, RASGEF1A, RASSF1, RASSF5, RB1, RBBP6, RBBP8, RBL1, RBL2, RBM8A, RECQL, RECQL4, REST, RET, RFC1, RFWD3, RHBDF2, RINT1, RIT1, RMI2, RNASEL, RNF135, RNF139, RNF168, RNF43, ROCK1, ROS1, RPL10, RPL11, RPL15, RPL19, RPL26, RPL27, RPL31, RPL35, RPL35A, RPL5, RPL9, RPS10, RPS15A, RPS17, RPS19, RPS20, RPS24, RPS26, RPS27, RPS28, RPS29, RPS7, RRAS, RTEL1, RUNX1, SAMD9, SAMD9L, SASH1, SBDS, SBF2, SDHA, SDHAF2, SDHB, SDHC, SDHD, SEC14L3, SEC23B, SERPINA7, SETBP1, SETD2, SFTPA2, SH2B3, SH2D1A, SHC1, SHOC2, SKP2, SLC19A2, SLC25A11, SLC25A38, SLC35C1, SLC37A4, SLC5A5, SLC5A9, SLX4, SMAD4, SMAD7, SMARCA4, SMARCB1, SMARCE1, SMO, SNX14, SOCS1, SOS1, SOS2, SPI1, SPRED1, SRGAP1, SRP54, SRP72, SRRM2, STAT4, STAT5A, STK11, STX11, STXBP2, SUFU, SYK, T, TAZ, TBC1D7, TCEB1, TCEB2, TCF7, TCF7L2, TCIRG1, TELO2, TERC, TERF2, TERF2IP, TERT, TET2, TFE3, TG, TGFA, THPO, TINF2, TMC6, TMC8, TMEM127, TNFRSF10B, TP53, TP53BP1, TPMT, TRIM24, TRIM28, TRIP13, TRNT1, TSC1, TSC2, TSHR, TSR2, TWSG1, TYK2, UACA, UBE2T, ULK4, UNC13D, UPF3B, USB1, VHL, VPS13B, VPS45, WAS, WIF1, WIPF1, WNT1, WNT10A, WNT10B, WNT3A, WNT7A, WNT8A, WRAP53, WRN, WT1, WWOX, XAF1, XIAP, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, XRCC6, YAP1, YARS2, ZBTB16, ZFHX4, ZSWIM7
  • Molecular confirmation of a clinical diagnosis
  • Identify the genetic basis of cancer for individuals who have features and/or a family history consistent with a hereditary cancer syndrome
  • To assist with decisions about treatment and clinical management of individuals with cancer
  • Identify family members at-risk to develop features associated with a specific hereditary cancer syndrome

**ATTENTION**
The Xpanded HereditaryCancer Panel performed on a singleton (proband only). This test is only available for order following an Hereditary Cancer Panel performed at GeneDx. For other Xpanded HereditaryCancer panel options, please go to the GeneDx Oncology Genetics Page, or contact our Customer Service Department at 1-888-729-1206 or zebras@genedx.com

Ordering

TH42d
6 weeks
2-5 mL Blood - Lavender Top Tube
Buccal Swabs | Dried Blood Spots

Billing

81415x1
No
No
For price inquiries please email zebras@genedx.com

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Forms and Documents

Test Details

A2ML1, ABCB7, ABL1, ABL2, ACBD5, ACD, AIP, AK2, AKR1C4, AKT1, AKT2, AKT3, ALAS2, ALK, ANKRD26, AP2S1, AP3B1, APAF1, APC, APPL1, ARAF, ARHGEF12, ARID1A, ARID2, ARNT, ASCC1, ASXL1, ATG2B, ATM, ATP4A, ATR, ATRIP, AXIN1, AXIN2, BAP1, BARD1, BAX, BBC3, BCL10, BCL2L1, BCL6, BCR, BDNF, BID, BIRC5, BLM, BMP1, BMP2, BMP4, BMPR1A, BRAF, BRCA1, BRCA2, BRIP1, BTK, BUB1, BUB1B, BUB3, C15ORF41, CAMTA1, CARD11, CASP3, CASP8, CASP9, CASR, CBFA2T3, CBL, CBX8, CCDC18, CCNA1, CCNB2, CCND1, CCND2, CCNE1, CD27, CD274, CD40LG, CDAN1, CDC42, CDC73, CDH1, CDH11, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CEBPA, CEP164, CEP57, CHAD, CHD8, CHEK1, CHEK2, CLCA2, CLPB, COQ6, CREBBP, CSF3R, CTBP1, CTC1, CTHRC1, CTNNA1, CTNNB1, CTR9, CUL2, CUL4B, CXCL8, CXCR4, CYLD, DCLRE1B, DDB1, DDB2, DDX41, DICER1, DIS3L2, DKC1, DNAJC21, DNMT3A, DOT1L, DUSP10, DUSP4, DUT, E2F3, EGF, EGFR, EGLN1, EGLN2, EIF2AK4, EIF3H, ELAC2, ELANE, ENG, EP300, EPAS1, EPCAM, EPHB2, EPHX1, EPO, ERBB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC6L2, ERCC8, ESR1, ETV6, EXT1, EXT2, EZH2, FAH, FAM175A, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FASN, FBXO24, FBXW7, FCGR2A, FGFR1, FGFR2, FGFR3, FH, FHIT, FLCN, FLT3, FOCAD, FOS, FOXE1, FOXO1, FOXO3, FOXO4, FOXP1, G6PC3, GALNT12, GATA1, GATA2, GEN1, GFI1, GLI1, GLI3, GLRX5, GMPS, GNA11, GNE, GP1BA, GPC3, GREM1, GSK3B, GSKIP, GSTP1, HABP2, HAUS3, HAVCR2, HAX1, HCCS, HEPACAM, HERC1, HGF, HIF1A, HIP1, HLTF, HMBS, HNF1A, HNF1B, HOXA11, HOXB13, HRAS, IDH1, IDH2, IGF1R, IKBKB, IL12RB1, IL2RA, IL6, IPMK, ITGA3, ITGB1, ITK, JAGN1, JAK1, JAK2, JAK3, JUN, KDM3B, KDR, KIF1B, KIF23, KIT, KITLG, KLF1, KLF6, KLK3, KRAS, LAMA5, LAMC1, LAMTOR2, LATS1, LATS2, LCK, LHCGR, LIG3, LIG4, LIMK2, LMO1, LRIG3, LYST, LZTR1, MAD2L2, MAF, MAFB, MAP2K1, MAP2K2, MAP2K4, MAP2K5, MAP3K1, MAP3K4, MAP3K6, MAP4K2, MAPK1, MAPK3, MAPKAP1, MASTL, MAX, MBD4, MC1R, MCM4, MDH2, MDM2, MECOM, MED12, MEN1, MET, MGMT, MITF, MLH1, MLH3, MN1, MPL, MRAS, MRE11A, MRPL3, MS4A1, MSH2, MSH3, MSH6, MSMB, MSR1, MST1, MTAP, MTOR, MUC1, MUTYH, MYC, MYCN, MYH8, MYH9, NABP1, NAT1, NBN, NCOA4, NDRG1, NDRG4, NDUFA13, NF1, NF2, NFIA, NFIX, NFKB1, NFKBIZ, NHP2, NKX2-1, NKX3-1, NLRP1, NLRP7, NOP10, NOS2, NOTCH1, NOTCH3, NPAT, NPM1, NR4A3, NR5A2, NRAS, NSD1, NTHL1, NTRK1, NTRK3, NUDT15, NUDT7, OBFC1, OCA2, OFD1, OGG1, OR5H14, PALB2, PALLD, PARN, PARP1, PAX2, PAX5, PBRM1, PCK2, PDE8B, PDGFB, PDGFRA, PDGFRB, PGM3, PGR, PHF6, PHOX2B, PIEZO1, PIF1, PIK3CA, PIK3R2, PITX1, PITX3, PKD1, PLAU, PLCB1, PLCG1, PLD1, PML, PMS1, PMS2, PNP, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLH, POT1, PPARG, PPM1D, PPP1CB, PPP2R5D, PRADC1, PRF1, PRKACA, PRKACB, PRKAR1A, PRKDC, PROM1, PRSS37, PSPH, PTCH1, PTCH2, PTCHD2, PTEN, PTGS2, PTK2, PTPN11, PUS1, RAB27A, RAB39B, RAB5B, RABL3, RAC1, RAC2, RAD17, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RALBP1, RALGDS, RARB, RASA1, RASA2, RASAL1, RASGEF1A, RASSF1, RASSF5, RB1, RBBP6, RBBP8, RBL1, RBL2, RBM8A, RECQL, RECQL4, REST, RET, RFC1, RFWD3, RHBDF2, RINT1, RIT1, RMI2, RNASEL, RNF135, RNF139, RNF168, RNF43, ROCK1, ROS1, RPL10, RPL11, RPL15, RPL19, RPL26, RPL27, RPL31, RPL35, RPL35A, RPL5, RPL9, RPS10, RPS15A, RPS17, RPS19, RPS20, RPS24, RPS26, RPS27, RPS28, RPS29, RPS7, RRAS, RTEL1, RUNX1, SAMD9, SAMD9L, SASH1, SBDS, SBF2, SDHA, SDHAF2, SDHB, SDHC, SDHD, SEC14L3, SEC23B, SERPINA7, SETBP1, SETD2, SFTPA2, SH2B3, SH2D1A, SHC1, SHOC2, SKP2, SLC19A2, SLC25A11, SLC25A38, SLC35C1, SLC37A4, SLC5A5, SLC5A9, SLX4, SMAD4, SMAD7, SMARCA4, SMARCB1, SMARCE1, SMO, SNX14, SOCS1, SOS1, SOS2, SPI1, SPRED1, SRGAP1, SRP54, SRP72, SRRM2, STAT4, STAT5A, STK11, STX11, STXBP2, SUFU, SYK, T, TAZ, TBC1D7, TCEB1, TCEB2, TCF7, TCF7L2, TCIRG1, TELO2, TERC, TERF2, TERF2IP, TERT, TET2, TFE3, TG, TGFA, THPO, TINF2, TMC6, TMC8, TMEM127, TNFRSF10B, TP53, TP53BP1, TPMT, TRIM24, TRIM28, TRIP13, TRNT1, TSC1, TSC2, TSHR, TSR2, TWSG1, TYK2, UACA, UBE2T, ULK4, UNC13D, UPF3B, USB1, VHL, VPS13B, VPS45, WAS, WIF1, WIPF1, WNT1, WNT10A, WNT10B, WNT3A, WNT7A, WNT8A, WRAP53, WRN, WT1, WWOX, XAF1, XIAP, XRCC1, XRCC2, XRCC3, XRCC4, XRCC5, XRCC6, YAP1, YARS2, ZBTB16, ZFHX4, ZSWIM7
  • Molecular confirmation of a clinical diagnosis
  • Identify the genetic basis of cancer for individuals who have features and/or a family history consistent with a hereditary cancer syndrome
  • To assist with decisions about treatment and clinical management of individuals with cancer
  • Identify family members at-risk to develop features associated with a specific hereditary cancer syndrome

**ATTENTION**
The Xpanded HereditaryCancer Panel will use a trio approach that includes concurrent analysis of the affected proband and both parents or other relatives. This test is only available for order following an Hereditary Cancer Panel performed at GeneDx. For other Xpanded HereditaryCancer panel options, please go to the GeneDx Oncology Genetics Page, or contact our Customer Service Department at 1-888-729-1206 or zebras@genedx.com

Ordering

TH42e
6 weeks
2-5 mL Blood - Lavender Top Tube
Buccal Swabs | Dried Blood Spots

Billing

81415x1
No
No
For price inquiries please email zebras@genedx.com

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.