Incontinentia Pigmenti (IP) is an X-linked dominant disorder of the skin, hair, teeth, and nails that progresses through four distinct stages and occurs in 1 in 50,000 newborns. Stage 1 is characterized by blisters or bullous eruptions on the extremities and trunk, and is typically evident at birth or within the first few postnatal months. Stage 2 is defined by a hypertrophic rash on the extremities and trunk and has been described as wart-like. This stage can last for several months or even years. Stage 3 develops with the appearance of brown hyperpigmentation along the lines of Blaschko. This is the most conspicuous sign of IP and manifests at about six months of age and lasts into adulthood. State 4 is marked by hypopigmentation of skin regions that are affected in previous stages. Affected female individuals can also suffer from retinal detachment and blindness, alopecia, conical or absent teeth, and mental retardation. Male fetuses with an inherited IP mutation usually do not survive gestation because this disorder causes is lethal in males.