Hailey-Hailey Disease (HHD) is a rare inherited skin disorder due to disturbed cell adhesion (acantholysis) in the upper layers of the epidermis. Hailey-Hailey disease usually develops in adolescence with a peak of onset between the second and fourth decade of life. Skin lesions begin with transient blistering, rapidly evolving into crusted erosions and scaling, fissured plaques. Primarily affected are the large skin folds (e.g. armpits, neck) and intertriginous areas (e.g. under the breasts, groin). The skin problems are exacerbated by trauma and irritation, for example due to heat, sweating, and friction. The disorder follows a chronic, recurrent course, often leading to discomfort, pain, and limitation of physical activity.