Familial Multiple Mole and Melanoma Syndrome

It is estimated that about 10% of melanoma is hereditary. Individuals with familial melanoma have a genetic predisposition to develop multiple clinically abnormal, histologically dysplastic, pigmented nevi distributed over both sun-exposed and sun-protected areas of the body. The age of onset tends to be earlier than in individuals with sporadic (non-hereditary) melanoma. Affected individuals also have an increased risk to develop ocular melanoma, and some families show a predisposition to pancreatic cancer.