A single XomeDx or GenomeSeqDx report will be issued on the patient. A separate report will not be issued for family members who submitted a specimen for trio/duo testing. If additional reports are requested for other affected family members, additional fees may apply. The report issued for the patient will contain variants in genes previously implicated in a human disease similar to that affecting the patient or in genes hypothesized to be related to the cause of the disease (candidate genes), based upon the function, tissue of expression, and phenotype of model organisms with alterations in the gene. Variants in candidate genes may also be reported based on internal data, such as observations of previous XomeDx cases with similar phenotypes and types of variations in the same gene.