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FAS (TNFRSF6) Gene Sequencing

FORMS AND DOCUMENTS

TEST DETAILS

Genes:
FAS (TNFRSF6)
Disorders:
Clinical Utility:
  • Confirmation of the clinical diagnosis
  • Differentiation from malignant forms of lymphoproliferation and from other sub-types of ALPS
  • Identification of relatives carrying the TNFRSF6 mutation who may have less severe disease
  • Development of an appropriate treatment plan for affected individuals
  • Development of an appropriate medical surveillance plan for relatives at risk of lymphoma
Lab Method:
Capillary Sequencing

ORDERING

Test Code:
138
Turnaround Time:
6-7 weeks
Preferred Specimen:
2-5 mL Blood - Lavender Top Tube

BILLING

CPT Codes:
81479x1
New York Approved:
No
ABN Required:
Yes
Billing Information:
View Billing Policy
ICD Codes:
  • 238.7: Other lymphatic and hematopoietic tissues
  • 202.x: Malignant neoplasms of lymphoid and histiocytic tissue, specific decimal required
  • 283: Autoimmune hemolytic anemias, Autoimmune hemolytic disease, Chronic cold hemagglutinin disease, Cold agglutinin disease or hemoglobinuria Hemolytic anemia
* For price inquiries please email zebras@genedx.com

REFERENCES

  1. Jackson C,.et al., (1999), Autoimmune lymphoproferative syndrome with defective Fas: genotype influences penetrance, Am. J. Hum. Genet. 64:1002-1004
  2. Vaishnaw, A, et al., (1999), The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations. J. Clin. Invest. 103: 355-363

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