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RET Select Exons Sequencing (MEN2B)

FORMS AND DOCUMENTS

TEST DETAILS

Genes:
RET
Disorders:
Clinical Utility:
  • Confirmation of a clinical diagnosis
  • Development of a screening program for the associated malignancies
  • Identification of at-risk family members
  • Prenatal diagnosis
Lab Method:
Capillary Sequencing

ORDERING

Test Code:
178
Turnaround Time:
4-5 weeks
Preferred Specimen:
2-5 mL Blood - Lavender Top Tube

BILLING

CPT Codes:
81404x1
List Price:
$500.00
Billing Information:
View Billing Policy
ICD Codes:
  • 191.9: Brain, unspecified Cranial fossa NOS
  • 193: Malignant neoplasm of thyroid gland, Thyroglossal duct
  • 255.6: Medulloadrenal hyperfunction, Catecholamine secretion by pheochromocytoma

REFERENCES

  1. Gimm, O. et al., Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation. J Clin Endocrinol Metab. 82: 3902-4, 1997
  2. Dr. Charis Eng, personal communication, 2004
  3. Eng, C. et al., Point mutation within the tyrosine kinase domain of the RET-proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumors. Hum Mol Genet. 3: 237-41, 1994

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