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CPVT Sequencing Panel

FORMS AND DOCUMENTS

TEST DETAILS

Genes:
CASQ2, KCNJ2, RYR2
Disorders:
Clinical Utility:
  • Confirmation of a clinical diagnosis in symptomatic patients
  • Risk assessment of asymptomatic family members of a proband with CPVT
  • Recurrence risk calculation
  • Differentiation of hereditary CPVT from other acquired or genetic heart conditions
  • Prenatal diagnosis in families with a known mutation
Lab Method:
Next-gen Sequencing
Clinical Sensitivity:
50%-70%

ORDERING

Test Code:
386
Turnaround Time:
8 weeks
Preferred Specimen:
2-5 mL Blood - Lavender Top Tube

BILLING

CPT Codes:
81403x1, 81405x1, 81408x1
New York Approved:
Yes
ABN Required:
Yes
Billing Information:
View Cardiology Billing Policy
ICD Codes:
  • 427: Cardiac dysrhythmias
  • 785: Tachycardia, unspecified Rapid heart beat
  • 426.9: Conduction disorder, unspecified Heart block NOS, Stokes-Adams syndrome
  • 427.9: Cardiac dysrhythmia, unspecified Arrhythmia (cardiac) NOS
* For price inquiries please email zebras@genedx.com

REFERENCES

  1. Online Mendelian Inheritance in Man. www.ncbi.nlm.nih.gov/sites/entrez?db=OMIM
  2. GeneReviews: Catecholaminergic Polymorhic Ventricular Tachycardia. Napolitano, C, Priori, S, and Bloise, R. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cvt Accessed September 24, 2009.
  3. Liu N et al. Catecholaminergic Polymorphic Ventricular Tachycardia. Progress in Cardiovascular Diseases. 51(1); 2008. 23-30
  4. Priori SG et al. Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation. 2002; 106: 69-74.
  5. Tester DJ et al. Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing. Heart Rhythm 3(7):800-805, 2006
  6. Bennett S. Pharmacogenomics. 5(4):433-8, 2004

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