Genetic Testing Company | The DNA Diagnostic Experts | GeneDx

In observance of the holidays, GeneDx will be closed for business on Thursday, December 25, 2014 and on Thursday, January 1, 2015. We will be unable to receive and process specimens. FedEx and UPS will also not be in operation. Except for the aforementioned dates, GeneDx will operate on our normal schedule (Monday-Saturday), including December 24th and December 31st.  If you have any questions or inquiries, please call us at 301-519-2100 or email us at zebras@genedx.com.

CPVT Sequencing Panel

FORMS AND DOCUMENTS

TEST DETAILS

Genes:
CASQ2, KCNJ2, RYR2
Disorders:
Clinical Utility:
  • Confirmation of a clinical diagnosis in symptomatic patients
  • Risk assessment of asymptomatic family members of a proband with CPVT
  • Recurrence risk calculation
  • Differentiation of hereditary CPVT from other acquired or genetic heart conditions
  • Prenatal diagnosis in families with a known mutation
Lab Method:
Next-gen Sequencing
Clinical Sensitivity:
50%-70%

ORDERING

Test Code:
386
Turnaround Time:
8 weeks
Preferred Specimen:
2-5 mL Blood - Lavender Top Tube

BILLING

CPT Codes:
81403x1, 81405x1, 81408x1
New York Approved:
Yes
ABN Required:
Yes
Billing Information:
View Cardiology Billing Policy
ICD Codes:
  • 427: Cardiac dysrhythmias
  • 785: Tachycardia, unspecified Rapid heart beat
  • 426.9: Conduction disorder, unspecified Heart block NOS, Stokes-Adams syndrome
  • 427.9: Cardiac dysrhythmia, unspecified Arrhythmia (cardiac) NOS
* For price inquiries please email zebras@genedx.com

REFERENCES

  1. Online Mendelian Inheritance in Man. www.ncbi.nlm.nih.gov/sites/entrez?db=OMIM
  2. GeneReviews: Catecholaminergic Polymorhic Ventricular Tachycardia. Napolitano, C, Priori, S, and Bloise, R. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cvt Accessed September 24, 2009.
  3. Liu N et al. Catecholaminergic Polymorphic Ventricular Tachycardia. Progress in Cardiovascular Diseases. 51(1); 2008. 23-30
  4. Priori SG et al. Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation. 2002; 106: 69-74.
  5. Tester DJ et al. Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing. Heart Rhythm 3(7):800-805, 2006
  6. Bennett S. Pharmacogenomics. 5(4):433-8, 2004

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