Genetic Testing Company | The DNA Diagnostic Experts | GeneDx

In observance of Thanksgiving, GeneDx will be closed and will not accept specimens on Thursday, November 26, 2015. We will accept specimens but operate on a modified schedule on Friday, November 27, 2015.  We will resume our normal schedule on Saturday, November 28, 2015.  If you have any questions or inquiries, please call us at 301-519-2100 or email us at

CASP8 Gene Sequencing



Clinical Utility:
  • Confirmation of the clinical diagnosis
  • Differentiation from malignant forms of lymphoproliferation and from other sub-types of ALPS
  • Development of an appropriate treatment plan for affected individuals
  • Development of an appropriate medical surveillance plan for relatives at risk of lymphoma
Lab Method:
Capillary Sequencing Reflex to Exon Array


Test Code:
Turnaround Time:
6-8 weeks
Preferred Specimen:
2-5 mL Blood - Lavender Top Tube
Alternative Specimen:
Oral Rinse (30-40 mL)


CPT Codes:
New York Approved:
ABN Required:
Billing Information:
View Billing Policy
* For ICD9 to ICD10 conversion please follow this link
ICD-9 Codes:
  • 283: Autoimmune hemolytic anemias, Autoimmune hemolytic disease, Chronic cold hemagglutinin disease, Cold agglutinin disease or hemoglobinuria Hemolytic anemia
  • 202.x: Malignant neoplasms of lymphoid and histiocytic tissue, specific decimal required
  • 238.7: Other lymphatic and hematopoietic tissues
* For price inquiries please email


  1. Zhu, S. et al., Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome, Human Genetics 119:284-294, 2006.
  2. Cerutti E. et al, Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome. BMC Immunol 8:22, 2007.
  3. Chun, H., et al., Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419: 395-399, 2002.
  4. Wang, J., et al., Inherited caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 47-58, 1999
  5. Su H et al, Genetic Defects of Apoptosis and Primary Immunodeficiency. Immunol Allergy Clin N Am, 28:329, 2008.

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