Genetic Testing Company | The DNA Diagnostic Experts | GeneDx

In observance of Independence Day, GeneDx will be closed on Friday, July 3rd, and Saturday, July 4th. Nevertheless, all specimens arriving on Friday, July 3rd will be accepted, accessioned and processed. We will not accept specimens on Saturday, July 4th. We will resume our normal Monday through Saturday schedule on Monday, July 6, 2015. Please also note that FedEx works on a modified schedule on Friday, July 3rd and FedEx and UPS are closed on Saturday, July 4th. If you have any questions or inquiries, please call us at 301-519-2100 or email us at zebras@genedx.com.

BrS Sequencing Panel

FORMS AND DOCUMENTS

TEST DETAILS

Genes:
CACNA1C, CACNB2, GPD1L, KCNE3, SCN1B, SCN3B, SCN5A
Disorders:
Clinical Utility:
  • Confirmation of a clinical diagnosis in Risk assessment of asymptomatic family members of a proband with Brugada syndrome
  • Recurrence risk calculation
  • Differentiation of hereditary BrS from other acquired or genetic heart conditions
  • Prenatal diagnosis in families with a known mutation
Lab Method:
Next-gen Sequencing
Clinical Sensitivity:
24%-41%

ORDERING

Test Code:
384
Turnaround Time:
8 weeks
Preferred Specimen:
2-5 mL Blood - Lavender Top Tube
Alternative Specimen:
Oral Rinse (30-40 mL), Dried Blood Spots

BILLING

CPT Codes:
81404x1, 81406x1, 81407x1
New York Approved:
Yes
ABN Required:
Yes
Billing Information:
View Cardiology Billing Policy
ICD Codes:
  • 746.89: Other Atresia of cardiac vein, Hypoplasia of cardiac vein, Congenital: cardiomegaly diverticulum, left ventricle pericardial defect
  • 427.9: Cardiac dysrhythmia, unspecified Arrhythmia (cardiac) NOS
  • 427: Cardiac dysrhythmias
  • 426.9: Conduction disorder, unspecified Heart block NOS, Stokes-Adams syndrome
* For price inquiries please email zebras@genedx.com

REFERENCES

  1. GeneReviews: Brugada syndrome. Brugada R, Brugada P, Brugada J and Hong K. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=brugada Accessed August 23, 2009.
  2. Fowler SJ and Priori SG. Curr Opin Cardiol. 24:74-81, 2008. (PubMed: 19102039)
  3. Ekhardt L. J Cardiovasc Electrophysiol. 18:422-424, 2007. (PubMed: 17286563)
  4. Hedley P et al., Hum Mutation. 30:1-11, 2009 (PubMed: 19606473)
  5. Bennett S. Pharmacogenomics. 5(4):433-8, 2004 (PubMed: 15165179)

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