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Multiple Endocrine Neoplasia type 2A
Familial Medullary Thyroid Carcinoma (FMTC)

  • RET ("Rearranged during Transfection")
Using genomic DNA obtained from buccal (cheek) swabs or blood in EDTA (lavender top tube), exons 10, 11, 13, and 14 of the 21-exon RET gene are screened by bi-directional sequence analysis. In MEN 2A, nearly all mutations occur in exons 10 and 11 of the RET gene. FMTC patients have shown a number of different mutations in the RET gene, most of which have been found in exons 10, 11, 13, or 14. This approach is expected to identify germline RET mutation in 95% of patients with MEN2A and ~88% of patients with FMTC.

Information Sheet, including prices and CPT codes Back to the List
Consent Document  
Genetic Test Sample Submission Form (Test Requisition Form) including Payment Options  
RET, FMTC, MEN, MEN2, MEN2A, thyroid, thyroid cancer, thyroid carcinoma, Sipple, Sipple Syndrome, medullary thyroid cancer, pheochromocytoma, parathyroid adenoma, hyperparathyroid, hyperparathyroidism, RET protooncogene, RET proto-oncogene, Hirschsprung disease, cutaneous lichen amyloidosis, Cushing syndrome, Hypertension, C-cell hyperplasia , pentagastrin, calcitonin

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