GeneDx :: Non-Standard Tissue Types

301-519-2100 • FAX 301-519-2892 • 207 PERRY PARKWAY GAITHERSBURG, MD 20877

Non-Standard Tissue Types

Other tissue types containing nucleated cells can often be tested even if not listed on that gene's Information Sheet. Nevertheless, some tissue types are not recommended and will only be accepted in extraordinary circumstances with prior approval.

Bone Marrow: 1-3 mL fresh sterile bone marrow in EDTA or Sodium Heparin. The anticoagulant should be clearly stated. BONE MARROW must be clearly indicated on the tube and paperwork. Ideal handling is to ship immediately at ambient temperature for overnight delivery with arrival Tuesday-Friday, but specimens can be refrigerated for 4 days before shipping. Specimens will be rejected if frozen, hemolyzed or clotted. Specimens older than 5 days can still be shipped; they will be tested if the yield and quality of DNA permit. Prior approval is not required.

Fresh Skin Biopsy for mRNA Sequencing:
Limited to the TGM1 gene and appropriate in special circumstances only. Must call to discuss and to obtain our RNA transport kit prior to performing the biopsy.

Fresh (Unfixed) Solid Tissue from Biopsy or Autopsy including Fetal Demise:
Call first for approval.
Tissues should be those with a high density of nuclei, such as liver, lymph node, or lung. The minimum specimen size is a cube 0.5 cm on each side. Flash-freeze and ship frozen on dry ice for overnight arrival on Tuesday- Friday. Specimens must arrive frozen. Isolation of usable DNA is not guaranteed.

Leukocytes Fixed for Cytogenetic Analysis:
NOT RECOMMENDED. Call first for approval.
If approved, mark the tube and paperwork "CAUTION FIXED CELLS". Isolation of usable DNA is not guaranteed. Ship at ambient temperature overnight.

Fixed, Paraffin-Embedded Solid Tissue or Cell Pellets:
NOT RECOMMENDED. Call first for approval.
Usually restricted to cases where the patient is deceased. Isolation of usable DNA is not guaranteed. The tissue must be cell-dense with abundant nuclei, e.g. kidney, liver, lung, pancreas, lymph node. The tissue should be a cube measuring 0.5 cm on each side, or the equivalent. Mounted slides are never accepted. If approved, ship or mail at ambient temperature. Specimens cannot be returned.

Shipping costs are generally the responsibility of the sender. GeneDx does not accept responsibility for shipping costs associated with samples sent to us.

Ship to:
GeneDx
207 Perry Parkway
Gaithersburg MD 20877

The GeneDx telephone number is 301-519-2100

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