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Specimen Requirements

 
Cardiology Specimen Requirements
Prenatal Specimen Requirements 

 

Blood Collection and Shipping Instructions – Including Cord Blood

Exceptions: Blood is accepted for all tests except if the patient has ever received a heterologous bone marrow transplant.
 Kits: Standard GeneDx Blood kit available free for US & Canadian clients
Volume: One EDTA (lavender top) tube containing 2-5 mL whole sterile blood. Several tests usually can be performed on one 3 mL blood specimen. 3-5 mL is the preferred volume for adults but 1-2 mL is acceptable for infants.
Labeling: Label with the patient name plus a second identifier such as date of birth, specimen ID or medical record number. If Cord Blood, state so on both the tube and the paperwork
Stability: Can be refrigerated up to 7 days before shipping. Blood specimens older than 7 days can still be shipped; they will be tested if the yield and quality of DNA permit. This statement supercedes all previous statements of shorter stability conditions for any test. 11-21-07
Rejection: Blood specimens will be rejected if frozen, hemolyzed or clotted.
Shipping: Ideal handling is to ship immediately at ambient temperature for overnight delivery with arrival Monday-Saturday. Specimens can be refrigerated for 7 days before shipping. In hot weather a cool pack can be enclosed. Shipping costs are generally the responsibility of the sender. GeneDx does not accept responsibility for shipping costs associated with samples sent to us.

Ship to:
GeneDx
207 Perry Parkway
Gaithersburg MD 20877
Phone: 1-301-519-2100

Buccal Brush Collection and Shipping Instructions

Exceptions: Please check test information sheets to see tests for which buccal brushes can be used
 Kits: Use only GeneDx buccal brush kits. Click here to order kits (Free for US & Canadian clients)
Volume: Two brushes with transport solution are included in each kit. Several tests usually can be performed on one pair of buccal brushes.
Labeling: Use the provided labels to put the patient name on both transport tubes. 
Stability: Stable at ambient temperature for 14 days after collection. Buccal specimens older than 14 days can still be shipped; they will be tested if the yield and quality of DNA permit.
Shipping: Using the mailer provided, return buccal brush specimens to GeneDx by postal service at ambient temperature. Shipping costs are generally the responsibility of the sender. GeneDx does not accept responsibility for shipping costs associated with samples sent to us.

Ship to:
GeneDx
207 Perry Parkway
Gaithersburg MD 20877
Phone: 1-301-519-2100

DNA Requirements

Laboratory Technique / Test Type Minimum concentration Minimum total amount Minimum quantity at minimum concentration
Conventional DNA Sequencing  50 ng/µL  5,000 ng (5 µg)  100 µL
Noonan Syndrome Spectrum Disorder Panel  50 ng/µL  6,000 ng (6 µg)  120 µL
XomeDx  50 ng/µL  15,000 ng (15 µg)  300 µL
All Cardiology Tests  50 ng/µL  20,000 ng (20 µg)  400 µL
Epilepsy Panel / Mito Nuclear Panels / Oncology Tests  50 ng/µL  20,000 ng (20 µg)  400 µL
GenomeDx OligoArray CGH  50 ng/µL  3,000 ng (3 µg)  60 µL
ExonArrayDx  50 ng/µL  3,000 ng (3 µg)  60 µL
CopyDx qPCR and/or MLPA  25 ng/µL  3,750 ng (3.75 µg)  150 µL

 

Kit: Standard GeneDx Blood Kit 
Labeling: Name of person or identifier, DNA concentration and volume MUST be provided on the specimen tube.
Stability: Ship DNA in sealed and protective packaging at ambient temperature, using a cool pack in hot weather.
Shipping: An express courier service is recommended for tracking purposes. Shipping costs are generally the responsibility of the sender. GeneDx does not accept responsibility for shipping costs associated with samples sent to us

Ship to:
GeneDx
207 Perry Parkway
Gaithersburg MD 20877
Phone: 1-301-519-2100

Prenatal/POC Specimen Collection and Shipping Instructions

Please call 301-519-2100 or email prenatal@genedx.com in advance to discuss prenatal cases.

Click here for prenatal specimen requirements.

Labeling: Label with the patient name plus a second identifier such as date of birth, specimen ID or medical record number. If the tissue source is Products of Conception (POC) state this clearly and state whether the tissue was fetal or placental in origin.
Kits:  Prenatal Amnio and CVS/POC kits are available free for US & Canadian clients
Stability: Cultures must be topped off with sterile medium immediately before shipping. All specimens, including Placental POCs will be tested for maternal cell contamination (MCC). Send a maternal blood or buccal sample for comparison. Other relatives' specimens may be required. If the tissue source is products of conception (POC) state this clearly and state whether the tissue was fetal or placental in origin. Placental POC cultures require maternal cell contamination testing and a maternal blood specimen is required for comparison
Shipping: Ship overnight at ambient temperature, to arrive Monday-Saturday. In hot weather a cool pack can be enclosed. Shipping costs are generally the responsibility of the sender. Shipping costs are generally the responsibility of the sender. GeneDx does not accept responsibility for shipping costs associated with samples sent to us.

Ship to:
GeneDx
207 Perry Parkway
Gaithersburg MD 20877
Phone: 1-301-519-2100

Other Cultured Adherent Cells* (not Amnio/CVS), Collection and Shipping Instructions

Volume: Send 2 T25 flasks near confluence, sterile. Please state the tissue of origin.
Labeling: Label with the patient name plus a second identifier such as date of birth, specimen ID or medical record number.
Stability: Cultures must be topped off with sterile medium immediately before shipping. Always establish and keep backup cultures but do not send them unless requested to do so by GeneDx.
Shipping: Ship overnight at ambient temperature, to arrive Monday-Saturday. In hot weather a cool pack can be enclosed. Shipping costs are generally the responsibility of the sender. GeneDx does not accept responsibility for shipping costs associated with samples sent to us.

Ship to:
GeneDx
207 Perry Parkway
Gaithersburg MD 20877
Phone: 1-301-519-2100

* Non-adherent cells such as lymphoid cell lines will be accepted but it is the sender’s responsibility to write “Non-Adherent Cells” with bold marker on the flask and paperwork.

Non-Standard Tissue Types

Other tissue types containing nucleated cells can often be tested even if not listed on that gene's Information Sheet. Nevertheless, some tissue types are not recommended and will only be accepted in extraordinary circumstances with prior approval.

Bone Marrow:
1-3 mL fresh sterile bone marrow in EDTA or Sodium Heparin. The anticoagulant should be clearly stated. BONE MARROW must be clearly indicated on the tube and paperwork. Ideal handling is to ship immediately at ambient temperature for overnight delivery with arrival Monday-Saturday, but specimens can be refrigerated for 4 days before shipping. Specimens will be rejected if frozen, hemolyzed or clotted. Specimens older than 5 days can still be shipped; they will be tested if the yield and quality of DNA permit. Prior approval is not required.

Fresh (Unfixed) Solid Tissue from Biopsy or Autopsy including Fetal Demise:

Call first for approval.
Tissues should be those with a high density of nuclei, such as liver, lymph node, lung or skin. The minimum specimen size is a cube 0.5 cm on each side. Flash-freeze and ship frozen on dry ice for overnight arrival on Monday-Saturday. Specimens must arrive frozen. Isolation of usable DNA is not guaranteed.

Leukocytes Fixed for Cytogenetic Analysis:
NOT RECOMMENDED. Call first for approval.
If approved, mark the tube and paperwork "CAUTION FIXED CELLS". Isolation of usable DNA is not guaranteed. Ship at ambient temperature overnight.

Fixed, Paraffin-Embedded Solid Tissue or Cell Pellets:
NOT RECOMMENDED. Call first for approval.
Usually restricted to cases where the patient is deceased. Isolation of usable DNA is not guaranteed. The tissue must be cell-dense with abundant nuclei, e.g. kidney, liver, lung, pancreas, lymph node. The tissue should be a cube measuring 0.5 cm on each side, or the equivalent. Mounted slides are never accepted. If approved, ship or mail at ambient temperature. Specimens cannot be returned.

Shipping costs are generally the responsibility of the sender. GeneDx does not accept responsibility for shipping costs associated with samples sent to us.

Ship to:
GeneDx
207 Perry Parkway
Gaithersburg MD 20877
Phone: 1-301-519-2100

 

 

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