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Oncology Genetics

 

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Oncology Genetic Testing Services

Over the past ten years, research has identified many genes associated with hereditary cancers. Some of these genes play a role in more than one type of cancer, and in most types of cancer several genes can cause the cancer. GeneDx has developed comprehensive panels to facilitate testing of all the important genes associated with inherited cancer, in a manner that provides rapid and accurate results and at typically no additional cost as compared to testing for a single gene. For a chart comparing the genes available on our panels, please click here.   For details on the tumor and cancer risks associated with various genes, please click here

Please download our Family History Questionnaire to assist in determining if the patient’s personal or family history is suggestive of a hereditary cancer syndrome and if they are a candidate for genetics follow-up.

Test

Gene(s)

Further Information

BRCA1 and BRCA2 Sequencing and Del/Dup Analysis

BRCA1, BRCA2

 Test Info Sheet  Clinician Guide
 Patient Guide  Spanish Patient Guide
 LOMN  
BRCA1 and BRCA2 Sequencing BRCA1, BRCA2
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  
BRCA1 and BRCA2 Del/Dup BRCA1, BRCA2
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

BRCA1 and BRCA2 Ashkenazi Founder Panel

BRCA1/ BRCA2 Targeted Pathogenic Variant Analysis (BRCA1 c.68_69delAG [also known as 185delAG or 187delAG], c.5266dupC [also known as 5382insC or 5385insC] and BRCA2 c.5946delT [also known as 6174delT])

  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

Comprehensive Cancer Panel (32 Genes)

APC, ATM, AXIN2, BARD1,  BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FANCC, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SCG5/GREM1, SMAD4, STK11, TP53, VHL, XRCC2

  Test Info Sheet  Patient Fact Sheet
 Panel Guide LOMN
High/Moderate Risk Panel (23 Genes) APC, ATM, BMPR1A, BRIP1, BRCA1, BRCA2, CDH1, CDKN2A, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53, VHL
  Test Info Sheet  Patient Fact Sheet
LOMN  

Breast Cancer High Risk Panel

(5 Genes)

BRCA1, BRCA2, CDH1, PTEN, TP53
  Test Info Sheet LOMN
  Patient Guide  Spanish Patient Guide

Breast Cancer High Risk Panel and PALB2

(6 Genes)

BRCA1, BRCA2, CDH1, PALB2, PTEN, TP53 
  Test Info Sheet
  Patient Guide  Spanish Patient Guide

Breast Cancer High/Moderate Risk Panel

(8 Genes)

ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, TP53

  Test Info Sheet   Patient Fact Sheet
  Patient Guide  Spanish Patient Guide
Breast/Ovarian Cancer Panel (20 Genes) ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FANCC, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, TP53, XRCC2
  Test Info Sheet   Patient Fact Sheet
  Patient Guide  Spanish Patient Guide
LOMN  

Lynch/Colorectal High Risk Panel (7 Genes)

APC, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2

  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  
Colorectal Cancer Panel (19 Genes) APC, ATM, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SCG5/GREM1, SMAD4, STK11, TP53
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

MSH2 Exon 1-7 Inversion Analysis

MSH2

    Test Info Sheet
Endometrial Cancer Panel (12 Genes)   BRCA1, BRCA2, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, POLD1, PMS2, PTEN, TP53
  Test Info Sheet LOMN
  Patient Guide  

Familial Cutaneous Malignant Melanoma

(2 Genes)

CDKN2A, CDK4

    Test Info Sheet

Pancreatic Cancer Panel (16 Genes)

APC, ATM, BRCA1, BRCA2, CDK4, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53, VHL, XRCC2

  Test Info Sheet   Clinician Guide
  Patient Guide LOMN

Pediatric Tumor Panel (27 genes)

ALK, APC, CDC73, DICER1, EPCAM, MEN1, MLH1, MSH2, MSH6, NF1, NF2, PHOX2B, PMS2, PRKAR1A, PTCH1, PTEN, RB1, RET, SMARCA4, SMARCB1, STK11, SUFU, TP53, TSC1, TSC2, VHL, WT1

  Test Info Sheet   Panel Fact Sheet

PGL/PCC (Paraganglioma/Pheochromocytoma) Panel (12 Genes)

FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

    Test Info Sheet             Panel Fact Sheet

Renal Cancer Panel (18 Genes)

BAP1, EPCAM, FH, FLCN, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL  
  Test Info Sheet   Panel Fact Sheet

 

Rest of Comprehensive Cancer Panel    

(if subpanel negative)

 
  Test Info Sheet LOMN

 

 

OncoGeneDx Custom Panel 

Test Gene(s) Further Information
Custom Panel (up to 61 genes) ALK, APC, ATM, AXIN2, BAP1, BARD1,  BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, FANCC, FH, FLCN, MAX, MEN1, MET, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, NF2, PALB2, PHOX2B, PMS2, POLD1, POLE, PRKAR1A, PTCH1, PTEN, RAD51C, RAD51D, RB1, RET, SCG5/GREM1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, WT1, XRCC2
 Test Info Sheet LOMN
  Lifetime Risk Chart  

 

 

 

Other Inherited Cancers 

Test Gene(s) Further Information
Birt-Hogg-Dube Syndrome  FLCN   Test Info Sheet
Bloom Syndrome  BLM   Test Info Sheet
Carney Complex  PRKAR1A   Test Info Sheet
Gorlin Syndrome  PTCH1   Test Info Sheet
Hereditary Leiomyomatosis and Renal Cell Cancer  FH   Test Info Sheet
Hyperparathyroidism-Jaw Tumor Syndrome  CDC73   Test Info Sheet
Juvenile Polyposis Syndrome  BMPR1A, SMAD4   Test Info Sheet
Li-Fraumeni Syndrome  TP53   Test Info Sheet
Multiple Endocrine Neoplasia, Type 1  MEN1   Test Info Sheet
Multiple Endocrine Neoplasia, Type 2A and 2B  RET   Test Info Sheet
PTEN Hamartoma Tumor Syndrome PTEN   Test Info Sheet
Peutz-Jeghers Syndrome STK11   Test Info Sheet
Von Hippel-Lindau Syndrome VHL   Test Info Sheet

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