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Oncology Genetics

 

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Oncology Genetic Testing Services

Over the past ten years, research has identified many genes associated with hereditary cancers. Some of these genes play a role in more than one type of cancer, and in most types of cancer several genes can cause the cancer. GeneDx has developed comprehensive panels to facilitate testing of all the important genes associated with inherited cancer, in a manner that provides rapid and accurate results and at typically no additional cost as compared to testing for a single gene. For a copy of our gene summary and lifetime risk chart, click here

Please download our Family History Questionnaire to assist in determining if the patient’s personal or family history is suggestive of a hereditary cancer syndrome and if they are a candidate for genetics follow-up.

Test

Gene(s)

Further Information

BRCA1 and BRCA2 Sequencing and Del/Dup Analysis

BRCA1, BRCA2

 Test Info Sheet  Clinician Guide
 Patient Guide  Spanish Patient Guide
 LOMN  
BRCA1 and BRCA2 Sequencing BRCA1, BRCA2
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  
BRCA1 and BRCA2 Del/Dup BRCA1, BRCA2
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

BRCA1 and BRCA2 Ashkenazi Founder Mutation

BRCA1/2 Targeted Mutation Analysis (BRCA1 c.68_69delAG [also known as 185delAG or 187delAG], c.5266dupC [also known as 5382insC or 5385insC] and BRCA2 c.5946delT [also known as 6174delT])

  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

Comprehensive Cancer Panel (29 Genes)

APC, ATM, AXIN2, BARD1,  BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FANCC, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53, VHL, XRCC2

  Test Info Sheet   Lifetime Risk Chart
LOMN  
High/Moderate Risk Panel (20 Genes) APC, ATM, BMPR1A, BRCA1, BRCA2, CDH1, CDKN2A, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, PTEN, SMAD4, STK11, TP53, VHL
  Test Info Sheet LOMN
Breast Cancer High Risk Panel (6 Genes) BRCA1, BRCA2, CDH1, PTEN, STK11, TP53
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

Breast Cancer High Risk Panel and PALB2 (7 Genes)

BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, TP53 
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide

 

Breast/Ovarian Cancer Panel (21 Genes)

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FANCC, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, TP53, XRCC2

  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  
Lynch/Colorectal High Risk Panel (7 Genes) APC, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2
  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

Colorectal Cancer Panel (16 Genes)

APC, ATM, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, SMAD4, STK11, TP53

  Test Info Sheet   Clinician Guide
  Patient Guide  Spanish Patient Guide
LOMN  

Pancreatic Cancer Panel (16 Genes)

APC, ATM, BRCA1, BRCA2, CDK4, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53, VHL, XRCC2

  Test Info Sheet   Clinician Guide
  Patient Guide LOMN

Endometrial Cancer Panel (11 Genes)

BRCA1, BRCA2, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, TP53

  Test Info Sheet   Clinician Guide
  Patient Guide LOMN

Familial Cutaneous Malignant Melanoma (2 Genes)

 CDKN2A/p16, CDK4    Test Info Sheet

Rest of Comprehensive Cancer Panel (if subpanel negative)

 

  Test Info Sheet

LOMN

 

 

OncoGeneDx Custom Panel 

Test Gene(s) Further Information
Custom Panel APC, ATM, AXIN2, BARD1,  BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FANCC, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53, VHL, XRCC2

 Test Info Sheet

LOMN

 

 

Other Inherited Cancers 

Test Gene(s) Further Information
Birt-Hogg-Dube Syndrome  FLCN   Test Info Sheet
Bloom Syndrome  BLM   Test Info Sheet
Carney Complex  PRKAR1A   Test Info Sheet
Gorlin Syndrome  PTCH1   Test Info Sheet
Hereditary Leiomyomatosis and Renal Cell Cancer  FH   Test Info Sheet
Hyperparathyroidism-Jaw Tumor Syndrome  CDC73   Test Info Sheet
Juvenile Polyposis Syndrome  BMPR1A, SMAD4   Test Info Sheet
Li-Fraumeni Syndrome  TP53   Test Info Sheet
Multiple Endocrine Neoplasia, Type 1  MEN1   Test Info Sheet
Multiple Endocrine Neoplasia, Type 2A and 2B  RET   Test Info Sheet
PTEN Hamartoma Tumor Syndrome PTEN   Test Info Sheet
Peutz-Jeghers Syndrome STK11   Test Info Sheet
Von Hippel-Lindau Syndrome VHL   Test Info Sheet

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